树状地衣东方松萝的抗皮肤真菌活性

Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis.

作者信息

Pathak Ashutosh, Upreti Dalip Kumar, Dikshit Anupam

机构信息

Biological Product Lab, Department of Botany, University of Allahabad, Allahabad 211002, India.

Lichenology Laboratory, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow 226001, India.

出版信息

Medicines (Basel). 2016 Sep 12;3(3):24. doi: 10.3390/medicines3030024.

DOI:10.3390/medicines3030024

PMID:28930134

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456250/

Abstract

In the present study, the new biological sources in the form of lichen Motyka was screened for its antidermatophytic potential. Six species of dermatophytes were chosen on the basis of their prevalence for antidermatophytic assays, and the Clinical Laboratory Standard Institute (CLSI)-recommended broth microdilution procedure was used to detect the efficacy of extract against dermatophytes. Thin layer chromatography of lichen extracts reveals the presence of two secondary metabolites viz. salazinic acid and usnic acid. extract exhibited promising antidermatophytic activity against all tested pathogens. Amongst all tested pathogens, exhibited most susceptibility towards extract, whereas exhibited the least susceptibility. Topical application of extract might be helpful in the cure of dermal infections.

摘要

在本研究中，对新的地衣形式的生物来源莫蒂卡进行了抗皮肤癣菌潜力的筛选。根据其在抗皮肤癣菌检测中的流行程度选择了六种皮肤癣菌，并采用临床实验室标准协会（CLSI）推荐的肉汤微量稀释法检测提取物对皮肤癣菌的疗效。地衣提取物的薄层色谱显示存在两种次生代谢产物，即水杨酸和松萝酸。提取物对所有测试病原体均表现出有前景的抗皮肤癣菌活性。在所有测试病原体中，对提取物最敏感，而对提取物最不敏感。提取物的局部应用可能有助于治疗皮肤感染。