Peres Nalu Teixera de Aguiar, Maranhão Fernanda Cristina Albuquerque, Rossi Antonio, Martinez-Rossi Nilce Maria
Universidade de São Paulo, SP, Brazil.
An Bras Dermatol. 2010 Sep-Oct;85(5):657-67. doi: 10.1590/s0365-05962010000500009.
Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphogenesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trigger the immune response against the infectious agent. The comprehension of the molecular aspects of these responses may help to establish new therapeutical strategies. In this review, different aspects of the biology of dermatophytes are addressed, with emphasis on the dermatophyte-host interaction and the mechanisms of antifungal resistance.
皮肤真菌病是人类最常见的感染之一，并且由于它们在免疫功能低下的患者中引起侵袭性感染，已成为一个重要的公共卫生问题。在感染过程中，皮肤癣菌与宿主的相互作用引发特定的代谢适应，使病原体能够黏附并穿透宿主组织、获取营养，并克服宿主防御机制。这种代谢转变以及代谢、形态发生和应激反应之间的相互作用是在几种病原体中已得到广泛研究的重要因素。宿主细胞也通过激活触发针对感染因子的免疫反应的细胞内信号通路来响应病原体刺激。对这些反应的分子层面的理解可能有助于建立新的治疗策略。在本综述中，我们探讨了皮肤癣菌生物学的不同方面，重点是皮肤癣菌与宿主的相互作用以及抗真菌耐药机制。
