Delbarre-Ladrat Christine, Salas Marcia Leyva, Sinquin Corinne, Zykwinska Agata, Colliec-Jouault Sylvia
Ifremer, Laboratoire Ecosystèmes Microbiens et Molécules Marines pour les Biotechnologies,Rue de l'Ile d'Yeu, BP 21105, 44311 Nantes, France.
Givaudan France SAS, 51110 Pomacle, France.
Microorganisms. 2017 Sep 20;5(3):63. doi: 10.3390/microorganisms5030063.
Many bacteria biosynthesize structurally diverse exopolysaccharides (EPS) and excrete them into their surrounding environment. The EPS functional features have found many applications in industries such as cosmetics and pharmaceutics. In particular, some EPS produced by marine bacteria are composed of uronic acids, neutral sugars, and -acetylhexosamines, and may also bear some functional sulfate groups. This suggests that they can share common structural features with glycosaminoglycans (GAG) like the two EPS (HE800 and GY785) originating from the deep sea. In an attempt to discover new EPS that may be promising candidates as GAG-mimetics, fifty-one marine bacterial strains originating from deep-sea hydrothermal vents were screened. The analysis of the EPS chemical structure in relation to bacterial species showed that , , and strains were the main producers. Moreover, they produced EPS with distinct structural features, which might be useful for targeting marine bacteria that could possibly produce structurally GAG-mimetic EPS.
许多细菌生物合成结构多样的胞外多糖（EPS），并将其分泌到周围环境中。EPS的功能特性在化妆品和制药等行业有许多应用。特别是，一些海洋细菌产生的EPS由糖醛酸、中性糖和N - 乙酰己糖胺组成，还可能带有一些功能性硫酸基团。这表明它们可以与糖胺聚糖（GAG）具有共同的结构特征，就像源自深海的两种EPS（HE800和GY785）一样。为了发现可能有望作为GAG模拟物的新EPS，对51株源自深海热液喷口的海洋细菌菌株进行了筛选。对与细菌种类相关的EPS化学结构分析表明，[此处可能遗漏了具体菌株信息]、[此处可能遗漏了具体菌株信息]和[此处可能遗漏了具体菌株信息]菌株是主要生产者。此外，它们产生的EPS具有独特的结构特征，这可能有助于靶向可能产生结构上类似GAG的EPS的海洋细菌。
