Ebbert Judith Ann, Donovan Kristine A, Lengacher Cecile A, Fabri Donna, Reich Richard, Daley Ellen, Thompson Erika Lynne, Wenham Robert M
Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
University of Florida Health, College of Nursing, 12901 Bruce B. Downs Blvd., Tampa, FL 33612 USA.
Medicines (Basel). 2015 Aug 31;2(3):236-250. doi: 10.3390/medicines2030236.
The purpose of this pilot study was to assess the feasibility of on-site complementary and alternative medicine (CAM) education sessions to maximize quality of life for women with ovarian cancer. The pilot intervention consisted of four weekly sessions, each focusing the techniques and benefits of a particular CAM topic (e.g., nutrition, massage, relaxation). Participants were recruited from the Center for Women's Oncology at H. Lee Moffitt Cancer Center from 2010 to 2012. Eligible participants had an ovarian cancer diagnosis with a life expectancy of at least 12 months, and were 18 years or older. The Gynecologic Oncology research nurse invited women in the outpatient clinic who matched the eligibility criteria. The research nurse explained the study and provided an informed consent form and return envelope. Because ovarian cancer is not only a rare cancer but, also, most patients seen at Moffitt have recurrent or advanced disease, many women did not have an adequate ECOG score. Many women who consented had rapid changes in health status, with morbidity and mortality outpacing recruitment of the 20 needed to proceed with the four education sessions. Baseline and follow-up surveys were conducted to assess changes in QOL, knowledge, and satisfaction with the intervention. While 27 women consented and 24 women completed the baseline survey, only five women participated in the intervention. The five women who participated were all white, and at time of consenting had a mean age of 60 (SD 9.08) and an average of 102 months (SD 120.65) since diagnosis, and were all on active treatment, except for one. The intervention pilot did not encounter difficulties with regard to recruitment, but suffered problems in achieving an adequate number of women to launch the on-site sessions because of rapidly changing morbidity and significant mortality. The team recognized that a larger-scaled intervention comprised of on-site sessions was impractical and compared attendance rates with a more convenient format currently underway in the Women's Oncology program at Moffitt. While low participation prevented an intervention analysis of scientific merit, the study data is informative with regard to barriers, facilitators, and alternative methods for sharing useful information to women with advanced ovarian cancer. The comparison strongly suggested that CAM education for women compromised by the disease and treatment associated with ovarian cancer would best be delivered in the convenient-access format that allowed remote access to live and recorded discussions of specific topics.
这项初步研究的目的是评估现场补充和替代医学（CAM）教育课程对于提高卵巢癌女性生活质量的可行性。初步干预包括每周一次的四次课程，每次课程聚焦于特定CAM主题（如营养、按摩、放松）的技巧和益处。参与者于2010年至2012年从H. Lee Moffitt癌症中心的女性肿瘤学中心招募。符合条件的参与者被诊断患有卵巢癌，预期寿命至少为12个月，且年龄在18岁及以上。妇科肿瘤学研究护士邀请门诊中符合资格标准的女性。研究护士解释了该研究，并提供了知情同意书和回邮信封。由于卵巢癌不仅是一种罕见癌症，而且在Moffitt就诊的大多数患者患有复发性或晚期疾病，许多女性的东部肿瘤协作组（ECOG）评分不足。许多同意参与的女性健康状况迅速变化，发病率和死亡率超过了进行四次教育课程所需招募的20名女性的速度。进行了基线和随访调查，以评估生活质量、知识以及对干预措施的满意度的变化。虽然有27名女性同意参与，24名女性完成了基线调查，但只有5名女性参与了干预。参与的5名女性均为白人，同意参与时的平均年龄为60岁（标准差9.08），自诊断以来平均为102个月（标准差120.65），除一人外均在接受积极治疗。干预试点在招募方面没有遇到困难，但由于发病率迅速变化和死亡率较高，在达到足够数量的女性以开展现场课程方面遇到了问题。该团队认识到由现场课程组成的更大规模干预是不切实际的，并将参与率与Moffitt女性肿瘤学项目目前正在进行的更便捷形式进行了比较。虽然低参与率妨碍了对具有科学价值的干预措施进行分析，但研究数据在障碍、促进因素以及向晚期卵巢癌女性分享有用信息的替代方法方面具有参考价值。比较结果强烈表明，对于因卵巢癌相关疾病和治疗而受到影响的女性，CAM教育最好以允许远程访问特定主题的现场和录制讨论的便捷访问形式提供。
