Monzote Lianet, Scull Ramón, Cos Paul, Setzer William N
Parasitology Department, Institute of Tropical Medicine Pedro Kouri, 10400 Havana, Cuba.
Department of Chemistry, Institute of Pharmacy and Food, University of Havana, 13600 Havana, Cuba.
Medicines (Basel). 2017 Jul 2;4(3):49. doi: 10.3390/medicines4030049.
The challenge in antimicrobial chemotherapy is to find safe and selective agents with potency that will not be compromised by previously developed resistance. Terrestrial plants could provide new leads to antibacterial, antifungal, or antiprotozoal activity. The essential oil (EO) of L. (Piperaceae) from Cuba was analyzed by gas chromatography-mass spectrometry (GC-MS). A cluster analysis of EO compositions reported in the literature was carried out. The EO was screened against a panel of microorganisms (bacteria, fungi, parasitic protozoa) as well as for cytotoxicity against human cells. In addition, a review of scientific literature and a bibliometric study was also conducted. A total of 90 compounds were identified in the EO, of which camphor (17.1%), viridiflorol (14.5%), and piperitone (23.7%) were the main components. The cluster analysis revealed at least nine different chemotypes. The EO did not show notable activity against bacteria or fungi, but was active against parasitic protozoa. The results from this study indicate from Cuba is a unique chemotype, support the importance of EOs as medicines, and demonstrate the promise of Cuban EO as a chemotherapeutic agent against parasitic protozoal infections.
抗微生物化疗面临的挑战是找到安全且具有选择性、效力不会因先前产生的耐药性而受损的药物。陆生植物可能为抗菌、抗真菌或抗原虫活性提供新线索。对来自古巴的胡椒科某种胡椒属植物的精油（EO）进行了气相色谱 - 质谱联用（GC - MS）分析。对文献中报道的精油成分进行了聚类分析。该精油针对一组微生物（细菌、真菌、寄生原生动物）进行了筛选，并检测了其对人类细胞的细胞毒性。此外，还进行了科学文献综述和文献计量学研究。在该精油中共鉴定出90种化合物，其中樟脑（17.1%）、绿花白千层醇（14.5%）和胡椒酮（23.7%）是主要成分。聚类分析揭示了至少九种不同的化学型。该精油对细菌或真菌未显示出显著活性，但对寄生原生动物有活性。这项研究的结果表明，来自古巴的该植物精油是一种独特的化学型，支持了精油作为药物的重要性，并证明了古巴植物精油作为抗寄生原生动物感染化疗药物的前景。
