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药用夏至草对2型糖尿病潜在作用的重新评估:初步结果为新研究方向提供指引

A Reassessment of the Marrubium Vulgare L. Herb's Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons.

作者信息

Rodríguez Villanueva Javier, Martín Esteban Jorge, Rodríguez Villanueva Laura

机构信息

Biomedical Sciences Department, Pharmacy and Pharmaceutical Technology Unit, Faculty of Pharmacy, University of Alcalá, Ctra. de Madrid-Barcelona (Autovía A2) Km. 33,600, 28805 Alcalá de Henares, Madrid, Spain.

Phytotherapy Faculty, University of Barcelona, Gran Via de les Corts Catalanes, 585, 08007 Barcelona, Spain.

出版信息

Medicines (Basel). 2017 Aug 2;4(3):57. doi: 10.3390/medicines4030057.

DOI:10.3390/medicines4030057
PMID:28930271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5622392/
Abstract

Despite the wide variety of pharmacological activities described for the L. herb, amazingly, only one clinical trial can be found in scientific literature. It was designed for the evaluation of its antidiabetic activity. Worse, the outcomes of this trial were contradictory to what previous in vivo mice assays had concluded. Therefore, should be ruled out due to its lack of therapeutic potential in diabetes? The authors suggest a reevaluation of the clinical trial methodology to establish valid and final results.

摘要

尽管对于拉布拉多茶(L. herb)描述了各种各样的药理活性,但令人惊讶的是,在科学文献中仅能找到一项临床试验。该试验旨在评估其抗糖尿病活性。更糟糕的是,该试验的结果与之前体内小鼠试验得出的结论相矛盾。那么,由于其在糖尿病方面缺乏治疗潜力,是否应该将其排除呢?作者建议重新评估临床试验方法以得出有效和最终的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b0/5622392/93c215dfce4c/medicines-04-00057-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b0/5622392/93c215dfce4c/medicines-04-00057-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b0/5622392/93c215dfce4c/medicines-04-00057-g001.jpg

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Pharm Biol. 2017 Dec;55(1):1337-1347. doi: 10.1080/13880209.2017.1297837.
2
Antinociceptive effect of extracts of Jacq. aerial parts.雅克气生部分提取物的抗伤害感受作用。
Avicenna J Phytomed. 2017 Jan-Feb;7(1):73-79.
3
Effects of the hydro-ethanolic extract of Marrubium vulgare in female rats.
Molecules. 2020 Jun 24;25(12):2898. doi: 10.3390/molecules25122898.
4
Does the World Need Plant Medicines?世界需要植物药吗?
Medicines (Basel). 2018 Apr 23;5(2):39. doi: 10.3390/medicines5020039.
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5
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J Intercult Ethnopharmacol. 2016 Dec 8;6(1):128-143. doi: 10.5455/jice.20161204021732. eCollection 2017 Jan-Mar.
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