以布洛芬为模板分子设计针对埃博拉病毒的药物。
Ibuprofen as a template molecule for drug design against Ebola virus.
机构信息
Department of Pathology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, USA.
Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
出版信息
Front Biosci (Landmark Ed). 2018 Jan 1;23(5):947-953. doi: 10.2741/4627.
The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.
2015 年西非和 2017 年刚果的埃博拉病毒爆发，凸显出迫切需要开发针对这种重要病原体的药物。此前，通过重新利用来自 DrugBank 的 6438 种药物的虚拟筛选，布洛芬被选为埃博拉病毒感染的可能抑制剂。进一步对接分析的结果以及在细胞培养中显示布洛芬具有可测量的抗埃博拉病毒作用的实验结果表明，布洛芬是开发用于治疗埃博拉病毒感染的药物的有前途的分子模板。
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