Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina, USA.
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Antimicrob Agents Chemother. 2019 Aug 23;63(9). doi: 10.1128/AAC.01142-19. Print 2019 Sep.
Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) inhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days.
盐酸奎宁是一种小分子、口服生物利用的药物，临床上已被用作抗疟药和许多其他用途。一个基于埃博拉病毒 (EBOV) 筛选数据训练的机器学习模型将奎宁鉴定为一种有效的（纳摩尔级）抑制剂。在目前的研究中，每天一次腹腔内给药 8 天，25mg/kg 的奎宁可保护 70%的小鼠（具有统计学意义）免受致死性的适应小鼠的埃博拉病毒的攻击。
