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用于药物递送的微流控技术:综述

Microfluidics technology for drug delivery: A review.

作者信息

Mancera-Andrade Elena I, Parsaeimehr Ali, Arevalo-Gallegos Alejandra, Ascencio-Favela Guadalupe, Parra Saldivar Roberto

机构信息

School of Engineering and Sciences, Tecnologico de Monterrey, Campus Monterrey Monterrey, Ave. Eugenio Garza Sada 2501, 64849, Monterrey, Nuevo Leon, Mexico.

School of Engineering and Sciences, Tecnologico de Monterrey, Campus Monterrey Monterrey, Ave. Eugenio Garza Sada 2501, 64849, Monterrey, Nuevo Leon, Mexico,

出版信息

Front Biosci (Elite Ed). 2018 Jan 1;10(1):74-91. doi: 10.2741/e809.

Abstract

Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory bench-top technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as precise dosage, ideal delivery, target-precise delivery, sustainable and controlled release, multiple dosing, and slight side effects. These advantages bring significant assets to the drug delivery systems. Microfluidic technology has been progressively used for fabrication of drug carriers, direct drug delivery systems, high-throughput screening, and formulation and immobilization of drugs. This review discusses the recent technological progress, outcomes and available opportunities for the usage of microfluidics systems in drug delivery systems.

摘要

微流控技术无疑是一项具有影响力的技术,它目前正在通过在微型芯片级设备上复制实验室台式技术,彻底改变化学和生物学研究。在药物递送科学领域,微流控技术具有诸多优势,如精确给药、理想递送、靶向精确递送、可持续和可控释放、多次给药以及轻微副作用。这些优势为药物递送系统带来了重要价值。微流控技术已逐渐应用于药物载体的制造、直接药物递送系统、高通量筛选以及药物的制剂和固定化。本综述讨论了微流控系统在药物递送系统中应用的最新技术进展、成果和可用机会。

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