Martensson E, Olofsson U, Heath A
Psychiatric Department III, Lillhagens Hospital, University of Gothenburg, Sweden.
Lancet. 1988 Feb 13;1(8581):327-8. doi: 10.1016/s0140-6736(88)91120-8.
The kinetics of methanol were examined in 84 chronic alcoholics admitted after drinking a cleansing solution containing 90% ethanol and 5% methanol. On admission, the average blood methanol concentration was 20 mmol/l (64 mg/dl) and blood ethanol concentration was 39 mmol/l (179 mg/dl). Although these patients were not treated with ethanol, and methanol concentrations remained high as blood ethanol concentrations fell to zero, no acidosis or other signs of classic methanol poisoning developed. The rate of metabolism of methanol was correlated to the initial ethanol concentration. To avoid unnecessary invasive therapy, treatment of methanol poisoning should be based on the case history, clinical signs, and laboratory features-not solely on blood methanol concentrations.
对84名饮用含90%乙醇和5%甲醇的清洁溶液后入院的慢性酗酒者的甲醇动力学进行了研究。入院时，平均血液甲醇浓度为20 mmol/l（64 mg/dl），血液乙醇浓度为39 mmol/l（179 mg/dl）。尽管这些患者未接受乙醇治疗，且随着血液乙醇浓度降至零，甲醇浓度仍保持较高水平，但未发生酸中毒或其他典型甲醇中毒迹象。甲醇的代谢速率与初始乙醇浓度相关。为避免不必要的侵入性治疗，甲醇中毒的治疗应基于病史、临床体征和实验室特征，而不仅仅基于血液甲醇浓度。
