基因组印记与致癌作用。
Genomic imprinting and carcinogenesis.
作者信息
Wilkins R J
机构信息
Department of Biochemistry, University of Otago Medical School, Dunedin, New Zealand.
出版信息
Lancet. 1988 Feb 13;1(8581):329-31. doi: 10.1016/s0140-6736(88)91121-x.
PMID:2893140
Abstract
Genomic imprinting might play an important part in the development of several tumours. It is suggested that in Wilms' tumorigenesis, imprinting normally renders inactive a transforming gene on the maternally derived chromosome 11, leaving intact the paternally inherited chromosome 11 and the Wilms' transforming gene that it carries. A similar mechanism might account for the inheritance patterns of other tumours.
摘要
基因组印记可能在多种肿瘤的发生发展中起重要作用。有人提出，在肾母细胞瘤的发生过程中，印记通常使母源11号染色体上的一个转化基因失活，而父源遗传的11号染色体及其携带的肾母细胞瘤转化基因保持完整。类似的机制可能解释其他肿瘤的遗传模式。
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