Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription.
作者信息
Arts E J, Wainberg M A
机构信息
McGill University AIDS Centre, Montreal, Quebec, Canada.
出版信息
Antimicrob Agents Chemother. 1996 Mar;40(3):527-40. doi: 10.1128/AAC.40.3.527.
Abstract
摘要
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Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription.人类免疫缺陷病毒逆转录过程中核苷类似物抗病毒活性及耐药性的机制
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本文引用的文献
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Analysis of Primer Extension and the First Template Switch during Human Immunodeficiency Virus Reverse Transcription.人类免疫缺陷病毒逆转录过程中引物延伸及首次模板转换的分析
J Biomed Sci. 1995 Oct;2(4):314-321. doi: 10.1007/BF02255218.
2
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA.在人类免疫缺陷病毒1型负链强终止DNA逆转录过程中，3'-脱氧核苷5'-三磷酸浓度对核苷类似物链终止的影响。
J Virol. 1996 Feb;70(2):712-20. doi: 10.1128/JVI.70.2.712-720.1996.
3
From RNA to DNA, why so many ribonucleotide reductases?从RNA到DNA，为何会有如此多的核糖核苷酸还原酶？
Science. 1993 Jun 18;260(5115):1773-7. doi: 10.1126/science.8511586.
4
Clinical correlates of in vitro HIV-1 resistance ot zidovudine. Results of the Multicentre Canadian AZT Trial.体外HIV-1对齐多夫定耐药性的临床相关性。加拿大多中心AZT试验结果。
AIDS. 1993 Feb;7(2):189-96. doi: 10.1097/00002030-199302000-00006.
5
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease.在疾病的临床潜伏期，HIV感染在淋巴组织中活跃且呈进行性发展。
Nature. 1993 Mar 25;362(6418):355-8. doi: 10.1038/362355a0.
6
Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.卡波韦和3'-叠氮-2',3'-双脱氧胸苷协同抑制1型人类免疫缺陷病毒的评估。
Antimicrob Agents Chemother. 1993 Jan;37(1):144-7. doi: 10.1128/AAC.37.1.144.
7
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.编码对2',3'-双脱氧肌苷和2',3'-双脱氧胞苷低水平1型人类免疫缺陷病毒耐药性的相同突变，赋予对2',3'-双脱氧-3'-硫代胞苷(-)对映体的高水平耐药性。
Antimicrob Agents Chemother. 1993 Jun;37(6):1390-2. doi: 10.1128/AAC.37.6.1390.
8
Effect of 3'-azido-3'-deoxythymidine on human immunodeficiency virus type 1 replication in human fetal brain macrophages.3'-叠氮-3'-脱氧胸苷对人胎儿脑巨噬细胞中1型人类免疫缺陷病毒复制的影响。
Antimicrob Agents Chemother. 1993 Jun;37(6):1305-12. doi: 10.1128/AAC.37.6.1305.
9
3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA.3'-叠氮-3'-脱氧胸苷单磷酸（AZT）：一种AZT末端DNA外切核酸酶修复的抑制剂。
Antimicrob Agents Chemother. 1993 Apr;37(4):918-20. doi: 10.1128/AAC.37.4.918.
10
Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells.叠氮胸苷、双脱氧胞苷和双脱氧肌苷在静息和活化外周血单个核细胞中的磷酸化差异
J Clin Invest. 1993 May;91(5):2326-33. doi: 10.1172/JCI116463.
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