Malazonia Ana, Zerekidze Tamar, Giorgadze Elen, Chkheidze Natia, Asatiani Ketevan
Tbilisi State University - Department of Endocrinology, Lubliana str. 2/6, Tbilisi 0159, Georgia.
Open Access Maced J Med Sci. 2017 Aug 12;5(5):613-617. doi: 10.3889/oamjms.2017.063. eCollection 2017 Aug 15.
The role of behavioural factors and sleep duration and quality is important in the pathogenesis of obesity. The aim of our study was to evaluate the effects of behavioural risk factors on melatonin secretion in women.
In total, 120 female patients were enrolled in the study and divided into two groups according to the body mass index. Detailed history, anthropometric measurements, urine and blood samples were evaluated for each patient.
Two groups significantly differed in weight, BMI, and waist circumference, and were 94.2 ± 14.9 kg, 33.4 ± 5.23 kg/m2 and 99.2 ± 12.6 cm for the study group and 56.0 ± 5.2 kg, 20.0 ± 1.8 kg/m2 and 60.1 ± 10.4 cm for the control group, respectively, sleep disruptions were detected in 48 patients from study group, with mean score 6.76 ± 3.6, and only 10 patients were detected in the control group, with mean score 4.42 ± 1.68. Eating disturbances were revealed in 66 patients from the study group and 21 patients from the control group. Melatonin levels were 17% higher in the study group, compared to control group.
Higher melatonin levels in patients with obesity and concomitant behavioural impairments may be due to its protective effect to fight free radicals and to induce vasodilatation. Further studies are needed to confirm our finding.
行为因素、睡眠时间和质量在肥胖发病机制中具有重要作用。本研究旨在评估行为危险因素对女性褪黑素分泌的影响。
本研究共纳入120例女性患者，根据体重指数分为两组。对每位患者进行详细病史、人体测量、尿液和血液样本评估。
两组在体重、体重指数和腰围方面存在显著差异，研究组分别为94.2±14.9千克、33.4±5.23千克/平方米和99.2±12.6厘米，对照组分别为56.0±5.2千克、20.0±1.8千克/平方米和60.1±10.4厘米。研究组48例患者检测到睡眠障碍，平均评分为6.76±3.6，对照组仅10例患者检测到睡眠障碍，平均评分为4.42±1.68。研究组66例患者和对照组21例患者出现饮食紊乱。与对照组相比，研究组褪黑素水平高17%。
肥胖及伴有行为障碍患者的褪黑素水平较高，可能是由于其对抗自由基和诱导血管舒张的保护作用。需要进一步研究来证实我们的发现。
