Yokote H, Kamata T, Toru S, Sanjo N, Yokota T
Department of Neurology, Nitobe Memorial Nakano General Hospital, Japan.
Department of Neurology, Musashino Red Cross Hospital, Japan.
Mult Scler J Exp Transl Clin. 2017 Sep 11;3(3):2055217317729688. doi: 10.1177/2055217317729688. eCollection 2017 Jul-Sep.
Although predicting future brain volume loss (BVL) in patients with multiple sclerosis (MS) is important, studies have shown only a few biomarkers that can predict BVL.
The aim of this study is to elucidate the association between longitudinal BVL and serum biomarker candidates.
This single-center, retrospective, observational study intended to cover MS patients during January 2008 to March 2016. Patients who underwent brain MRI two times at intervals of >24 months and had a blood test to measure biomarker candidates at the time or within three months of the MRI scan were included. Evaluation of brain volume was performed by using SIENAX and SIENA in the FMRIB software library.
Twenty-three patients with MS were included in this study. We found that serum retinol binding protein (RBP) levels were significantly correlated with percentage brain volume change (PBVC) ( = 0.0079). Furthermore, best subset selection of multiple linear regression models identified baseline normalized brain volume and serum RBP as the best predictors of PBVC.
Our study shows that lower serum retinol levels are associated with greater longitudinal BVL and that serum RBP and can be a predictor of BVL.
尽管预测多发性硬化症（MS）患者未来的脑容量损失（BVL）很重要，但研究表明只有少数生物标志物可以预测BVL。
本研究的目的是阐明纵向BVL与血清生物标志物候选物之间的关联。
这项单中心、回顾性、观察性研究旨在涵盖2008年1月至2016年3月期间的MS患者。纳入了间隔超过24个月进行两次脑部MRI检查且在MRI扫描时或扫描后三个月内进行血液检查以测量生物标志物候选物的患者。使用FMRIB软件库中的SIENAX和SIENA对脑容量进行评估。
本研究纳入了23例MS患者。我们发现血清视黄醇结合蛋白（RBP）水平与脑容量变化百分比（PBVC）显著相关（=0.0079）。此外，多元线性回归模型的最佳子集选择确定基线标准化脑容量和血清RBP是PBVC的最佳预测指标。
我们的研究表明，较低的血清视黄醇水平与更大的纵向BVL相关，并且血清RBP可以作为BVL的预测指标。
