Fiorelli Alfonso, Caronia Francesco, Prencipe Aldo, Santini Mario, Stiles Brendon
Thoracic Surgery Unit, Università della Campania Luigi Vanvitelli, Naples, Italy.
Thoracic Surgery Unit, Istituto Oncologico del Mediterraneo, Catania, Italy.
J Thorac Dis. 2017 Aug;9(8):2339-2343. doi: 10.21037/jtd.2017.06.119.
A best evidence topic in thoracic surgery was written addressing whether video-assisted thoracoscopic surgery (VATS) talc pleurodesis could be justified in patients with pleural effusion (PE) after coronary artery bypass graft (CABG) surgery and no-responded to repeated thoracentesis. Ten papers were identified to answer the question. Of these, two were case-series study including ≥4 patients, 7 retrospective analytical studies, and one observational study but no randomized controlled trial (RCTs) was included in the analysis. The score of the level of evidence was low; only one study presented a level of evidence of 2, 7 studies a level of 3b; and two studies a level of evidence of 4. The incidence of symptomatic post-CABG PE ranged from 2% to 9.7%. Management strategies included medical management, thoracentesis, and/or surgical drainage. Most of the authors treated early and late PE with thoracentesis or chest drainage, while VATS with pleurodesis was reserved only for selected patients with persistent effusion after repeating thoracentesis and/or chest drainage. All studies but one do not include follow-up, thus rendering it difficult to define the real role of thoracentesis or chest drainage as definitive treatments for effusion, given the incomplete data regarding how many patients' effusions recur. Conversely, with follow up reported, no case of recurrence was found after VATS procedure. In patients who underwent delayed VATS, it was common to identify the formation of tenacious peel that trapped the lung. In three cases conversion to thoracotomy was required to decorticate the inflammatory peel that covered the pleura and did not allow the lung re-expansion. However, only five papers showed that VATS for management of post-CABG PEs is safe and efficacious and its use could help to prevent trapped lung through the resection of adhesions and loculations sometimes associated with multiple previous thoracentesis or chest drainage. As the low grade of evidence from the present analysis, future randomized controlled studies are wanted to define the real effectiveness of VATS in this field.
撰写了一篇胸外科最佳证据主题文章,探讨在冠状动脉旁路移植术(CABG)后出现胸腔积液(PE)且反复胸腔穿刺无反应的患者中,电视辅助胸腔镜手术(VATS)滑石粉胸膜固定术是否合理。共确定了10篇论文来回答该问题。其中,2篇为病例系列研究(包含≥4例患者),7篇为回顾性分析研究,1篇为观察性研究,但分析中未纳入随机对照试验(RCT)。证据水平评分较低;只有1项研究呈现的证据水平为2级,7项研究为3b级,2项研究为4级。CABG术后有症状的PE发生率在2%至9.7%之间。管理策略包括药物治疗、胸腔穿刺和/或手术引流。大多数作者对早期和晚期PE采用胸腔穿刺或胸腔引流治疗,而VATS胸膜固定术仅用于反复胸腔穿刺和/或胸腔引流后仍有持续性积液的特定患者。除1项研究外,所有研究均未包括随访,因此鉴于关于多少患者积液复发的不完整数据,难以确定胸腔穿刺或胸腔引流作为积液确定性治疗方法的真正作用。相反,有随访报告显示,VATS手术后未发现复发病例。在接受延迟VATS的患者中,常见的情况是发现形成了包裹肺的坚韧粘连。有3例需要转为开胸手术,以剥除覆盖胸膜且不允许肺复张的炎性粘连。然而,只有5篇论文表明VATS用于管理CABG术后PE是安全有效的,其应用有助于通过切除有时与多次先前胸腔穿刺或胸腔引流相关的粘连和分隔来预防肺被包裹。由于目前分析的证据等级较低,需要未来进行随机对照研究来确定VATS在该领域的真正有效性。