Garber Ari, Arora Zubin, Welch Nicole, Lapinski James, Burke Carol A
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH.
Department of Pathology, Cleveland Clinic, Cleveland, OH.
ACG Case Rep J. 2017 Sep 13;4:e108. doi: 10.14309/crj.2017.108. eCollection 2017.
Esophageal mucosal calcinosis (EMC) is a rare cause of dysphagia with high morbidity. We present a patient who experienced melena and 3 months of solid and liquid dysphagia along with bilateral lower extremity pain, erythema, and edema later determined to be calcific uremic arteriolopathy (CUA), or calciphylaxis. An esophagogastroduodenoscopy revealed nodularity and linear ulcerations in the upper third of the esophagus. Histology showed active inflammation and ulceration with small foci of subepithelial and intraepithelial calcification consistent with EMC. There is no known treatment for this disorder. Sodium thiosulfate, typically used to treat CUA, did not improve her dysphagia.
食管黏膜钙化症（EMC）是吞咽困难的一种罕见病因，发病率较高。我们报告一例患者，该患者出现黑便以及3个月的固体和液体吞咽困难，同时伴有双侧下肢疼痛、红斑和水肿，后来被诊断为钙化性尿毒症小动脉病（CUA），即钙过敏。食管胃十二指肠镜检查显示食管上三分之一处有结节和线性溃疡。组织学检查显示有活动性炎症和溃疡，伴有上皮下和上皮内小灶钙化，符合EMC表现。这种疾病尚无已知的治疗方法。通常用于治疗CUA的硫代硫酸钠并未能改善她的吞咽困难。
