Young W S, Warden M, Mezey E
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Md.
Neuroendocrinology. 1987 Nov;46(5):439-44. doi: 10.1159/000124858.
In situ hybridization histochemistry was used to locate cells containing tyrosine hydroxylase (TH) mRNA in the hypothalami of salt-loaded and Brattleboro rats. The hyperosmotic plasma conditions found in these animals, as compared to control animals, was associated with an increase in detectable TH mRNA-producing cells in the paraventricular and supraoptic nuclei. These results suggest that dopamine synthesized by neurons of those nuclei may participate in the regulation of neuropeptide synthesis and release within the nuclei and the posterior pituitary.
采用原位杂交组织化学法，在盐负荷大鼠和布氏大鼠的下丘脑定位含酪氨酸羟化酶（TH）mRNA的细胞。与对照动物相比，这些动物出现的高渗血浆状况与室旁核和视上核中可检测到的产生TH mRNA的细胞增多有关。这些结果表明，由这些核的神经元合成的多巴胺可能参与这些核以及垂体后叶内神经肽合成与释放的调节。
