1 Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
2 School of Management, Harbin Institute of Technology, Harbin, P. R. China.
Stat Methods Med Res. 2019 Feb;28(2):503-514. doi: 10.1177/0962280217729843. Epub 2017 Sep 21.
Large-scale public health prevention initiatives and interventions are a very important component to current public health strategies. But evaluating effects of such large-scale prevention/intervention faces a lot of challenges due to confounding effects and heterogeneity of study population. In this paper, we will develop metrics to assess the risk for suicide events based on causal inference framework when the study population is heterogeneous. The proposed metrics deal with the confounding effect by first estimating the risk of suicide events within each of the risk levels, number of prior attempts, and then taking a weighted sum of the conditional probabilities. The metrics provide unbiased estimates of the risk of suicide events. Simulation studies and a real data example will be used to demonstrate the proposed metrics.
大规模的公共卫生预防措施和干预措施是当前公共卫生策略的一个非常重要的组成部分。但是,由于混杂效应和研究人群的异质性,评估这种大规模预防/干预措施的效果面临着许多挑战。在本文中,我们将开发基于因果推理框架的指标来评估研究人群异质性时自杀事件的风险。所提出的指标通过首先估计每个风险水平、先前尝试次数内的自杀事件风险,然后对条件概率进行加权和来处理混杂效应。该指标提供了自杀事件风险的无偏估计。将进行模拟研究和真实数据示例来说明所提出的指标。