MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou 510631, Guangdong, China.
Guangzhou Micro-shot Technology Co., Ltd, Guangzhou 510663, Guangdong, China.
Curr Med Chem. 2019;26(10):1788-1805. doi: 10.2174/0929867324666170920152529.
Ascribe to the unique two-dimensional planar nanostructure with exceptional physical and chemical properties, black phosphorous (BP) as the emerging inorganic twodimensional nanomaterial with high biocompatibility and degradability has been becoming one of the most promising materials of great potentials in biomedicine. The exfoliated BP sheets possess ultra-high surface area available for valid bio-conjugation and molecular loading for chemotherapy. Utilizing the intrinsic near-infrared optical absorbance, BPbased photothermal therapy in vivo, photodynamic therapy and biomedical imaging has been realized, achieving unprecedented anti-tumor therapeutic efficacy in animal experiments. Additionally, the BP nanosheets can strongly react with oxygen and water, and finally degrade to non-toxic phosphate and phosphonate in the aqueous solution. This manuscript aimed to summarize the preliminary progresses on theranostic application of BP and its derivatives black phosphorus quantum dots (BPQDs), and discussed the prospects and the state-of-art unsolved critical issues of using BP-based material for theranostic applications.
赋予具有特殊物理和化学性质的独特二维平面纳米结构，黑磷（BP）作为一种新兴的具有高生物相容性和可降解性的无机二维纳米材料，已成为生物医学中最有前途的材料之一。剥离的 BP 片具有超高的表面积，可用于有效的生物偶联和化疗分子负载。利用内在的近红外光吸收，实现了基于 BP 的光热疗法、光动力疗法和生物医学成像，在动物实验中实现了前所未有的抗肿瘤治疗效果。此外，BP 纳米片可以与氧气和水强烈反应，最终在水溶液中降解为无毒的磷酸盐和膦酸盐。本文旨在总结 BP 及其衍生物黑磷量子点（BPQDs）的治疗应用的初步进展，并讨论基于 BP 的材料在治疗应用中的前景和尚未解决的关键问题。
