Department of Orthopedic Surgery , Shanghai Jiao Tong University affiliated Sixth People's Hospital , Shanghai 200233 , P.R. China.
ACS Appl Mater Interfaces. 2019 Dec 4;11(48):44949-44960. doi: 10.1021/acsami.9b15569. Epub 2019 Nov 21.
Metal-free layered black phosphorus (BP) nanosheets with an excellent photothermal effect and large surface areas have been widely applied in biomedicine but are easily oxidized in ambient conditions yielding insulating phosphorus oxides adsorbed on its surface. Several chemical-functionalized strategies have been explored to protect thin layers of BP; however, the performance of passivated BP often decreases significantly, falling behind the single BP due to the strong structure perturbation. Herein, we designed and constructed 0D/2D hybrid photothermal agents by assembling NIR-II-responsive carbon dots (NIR-II-CDs) on BP nanosheets. NIR-II-CDs improve the ambient stability of BP by isolating them from water and oxygen and enhance the photothermal properties of BP nanosheets. Such NIR-II-CD/BP hybrids strengthen the light-harvesting ability, achieving high photothermal conversion efficiencies in the NIR-I (77.3%) and NIR-II (61.4%) windows, which is significantly higher than that of pristine BP (49.5 and 28.4% at 808 and 1064 nm). Owing to the intrinsic advantage of 1064 nm laser and the excellent PTT effect of our NIR-II-CD/BP hybrids, complete tumor eradication was realized in a deep-tissue tumor model.
无金属层状黑磷 (BP) 纳米片具有优异的光热效应和较大的表面积，已广泛应用于生物医学领域，但在环境条件下容易氧化，生成吸附在其表面的绝缘磷氧化物。已经探索了几种化学功能化策略来保护 BP 的薄层；然而，由于强烈的结构干扰，钝化后的 BP 的性能通常会显著下降，落后于单 BP。在此，我们通过将近红外二区响应性碳点 (NIR-II-CDs) 组装在 BP 纳米片上，设计并构建了 0D/2D 混合光热剂。NIR-II-CDs 通过将 BP 纳米片与水和氧气隔离来提高其环境稳定性，并增强 BP 纳米片的光热性能。这种 NIR-II-CD/BP 杂化材料增强了光捕获能力，在近红外-I（77.3%）和近红外-II（61.4%）窗口实现了高的光热转换效率，明显高于原始 BP（808nm 和 1064nm 时分别为 49.5%和 28.4%）。由于 1064nm 激光的固有优势和我们的 NIR-II-CD/BP 杂化材料优异的 PTT 效果，在深部组织肿瘤模型中实现了完全的肿瘤消除。
