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多发性硬化症患者的双重任务训练:一项可行性随机对照试验。

Dual task training in persons with Multiple Sclerosis: a feasability randomized controlled trial.

机构信息

1 Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, USA.

2 Department of Exercise Science, Cleveland State University, USA.

出版信息

Clin Rehabil. 2017 Oct;31(10):1322-1331. doi: 10.1177/0269215517698028. Epub 2017 Mar 20.

Abstract

OBJECTIVE

To determine the feasibility of dual task training in persons with Multiple Sclerosis.

DESIGN

Randomized, single-blinded controlled trial.

SETTING

University research laboratory.

PARTICIPANTS

A total of 234 individuals inquired about the investigation. After screening, 20 individuals with multiple sclerosis who self-reported problems with multitasking and were ambulatory volunteered for the investigation. 14 participants completed the post-assessment following the 12-week intervention.

INTERVENTION

Participants were randomly assigned to either single task training program which focused on balance and walking function ( n=6) or dual task training program that incorporated cognitive tasks in balance and walking training ( n=8).

MEASURES

Before and after the 12-week interventions participants underwent assessments of walking; dual task walking; balance (Berg Balance Scale and balance confidence) and cognition as indexed by the Brief International Cognitive Assessment for MS.

RESULTS

There was an 8.5% recruitment rate, a 70% retention rate, and a 100% adherence rate. There was a trend for dual task gait speed to improve in the dual task training group following the intervention (Pre: task 1: 109.8±39, task 2: 104.2±34.1; Post: task 1:127.6±40.1, task 2: 122.8±37.4; P=0.14; η = 0.24). There was also a trend for the dual task training group (28.1) to have greater performance than the control group (24.7) on visuospatial memory ( P=0.10; η= 0.23). There were no changes in cognitive performance during walking trials.

CONCLUSIONS

The study procedures were found to be feasible and improvements should be made in recruitment efforts going forward. Further examination of dual task training programs in individuals with multiple sclerosis is warranted.

摘要

目的

确定多发性硬化症患者进行双重任务训练的可行性。

设计

随机、单盲对照试验。

地点

大学研究实验室。

参与者

共有 234 人询问了该调查。经过筛选,共有 20 名多发性硬化症患者自我报告存在多任务处理问题且能行走,自愿参加了该调查。12 周干预后,有 14 名参与者完成了后续评估。

干预

参与者被随机分配到单一任务训练程序组,该程序组侧重于平衡和行走功能(n=6)或双重任务训练程序组,该程序组将认知任务纳入平衡和行走训练(n=8)。

测量

在 12 周干预前后,参与者接受了行走、双重任务行走、平衡(Berg 平衡量表和平衡信心)和认知(以多发性硬化症的简短国际认知评估为指标)的评估。

结果

招募率为 8.5%,保留率为 70%,依从率为 100%。在干预后,双重任务训练组的双重任务步态速度有改善的趋势(干预前:任务 1:109.8±39,任务 2:104.2±34.1;干预后:任务 1:127.6±40.1,任务 2:122.8±37.4;P=0.14;η=0.24)。双重任务训练组(28.1)在视空间记忆方面的表现也优于对照组(24.7),有趋势差异(P=0.10;η=0.23)。在行走试验中,认知表现没有变化。

结论

研究程序被发现是可行的,未来应在招募工作中做出改进。有必要进一步研究多发性硬化症患者的双重任务训练计划。

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