a Section of Molecular Biology, Division of Biological Sciences , University of California, San Diego , La Jolla , CA , USA.
Cell Cycle. 2017;16(21):2037-2045. doi: 10.1080/15384101.2017.1376149. Epub 2017 Sep 21.
Peroxisomes are essential and dynamic organelles that allow cells to rapidly adapt and cope with changing environments and/or physiological conditions by modulation of both peroxisome biogenesis and turnover. Peroxisome biogenesis involves the assembly of peroxisome membranes and the import of peroxisomal matrix proteins. The latter depends on the receptor, PEX5, which recognizes peroxisomal matrix proteins in the cytosol directly or indirectly, and transports them to the peroxisomal lumen. In this review, we discuss the role of PEX5 ubiquitination in both peroxisome biogenesis and turnover, specifically in PEX5 receptor recycling, stability and abundance, as well as its role in pexophagy (autophagic degradation of peroxisomes).
过氧化物酶体是必不可少的和动态的细胞器，通过调节过氧化物酶体的生物发生和周转率，使细胞能够快速适应和应对不断变化的环境和/或生理条件。过氧化物酶体的生物发生涉及过氧化物酶体膜的组装和过氧化物酶体基质蛋白的导入。后者依赖于受体 PEX5，它直接或间接地识别细胞质中的过氧化物酶体基质蛋白，并将它们运输到过氧化物酶体腔中。在这篇综述中，我们讨论了 PEX5 泛素化在过氧化物酶体生物发生和周转率中的作用，特别是在 PEX5 受体回收、稳定性和丰度，以及在过氧化物酶体自噬（过氧化物酶体的自噬降解）中的作用。
