Pharmacy School, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Taipei Cancer Center, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Nutrients. 2017 Sep 21;9(10):1046. doi: 10.3390/nu9101046.
Preclinical and clinical studies have offered evidence for protective effects of various polyphenol-rich foods against cardiovascular diseases, neurodegenerative diseases, and cancers. Resveratrol is among the most widely studied polyphenols. However, the preventive and treatment effectiveness of resveratrol in cancer remain controversial because of certain limitations in existing studies. For example, studies of the activity of resveratrol against cancer cell lines in vitro have often been conducted at concentrations in the low μM to mM range, whereas dietary resveratrol or resveratrol-containing wine rarely achieve nM concentrations in the clinic. While the mechanisms underlying the failure of resveratrol to inhibit cancer growth in the intact organism are not fully understood, the interference by thyroid hormones with the anticancer activity of resveratrol have been well documented in both in vitro and xenograft studies. Thus, endogenous thyroid hormones may explain the failure of anticancer actions of resveratrol in intact animals, or in the clinic. In this review, mechanisms involved in resveratrol-induced antiproliferation and effects of thyroid hormones on these mechanisms are discussed.
临床前和临床研究为各种富含多酚的食物预防心血管疾病、神经退行性疾病和癌症提供了证据。白藜芦醇是研究最多的多酚之一。然而，由于现有研究的某些局限性，白藜芦醇在癌症中的预防和治疗效果仍存在争议。例如，体外研究白藜芦醇对癌细胞系的活性通常在低 μM 到 mM 范围内进行，而饮食中的白藜芦醇或含白藜芦醇的葡萄酒在临床上很少达到 nM 浓度。虽然白藜芦醇在完整生物体中不能抑制肿瘤生长的机制尚未完全阐明，但甲状腺激素对其抗癌活性的干扰在体外和异种移植研究中都有很好的记录。因此，内源性甲状腺激素可能解释了白藜芦醇在完整动物或临床中的抗癌作用失败的原因。在这篇综述中，讨论了白藜芦醇诱导的增殖抑制作用的机制以及甲状腺激素对这些机制的影响。
