McCubrey James A, Lertpiriyapong Kvin, Steelman Linda S, Abrams Steve L, Yang Li V, Murata Ramiro M, Rosalen Pedro L, Scalisi Aurora, Neri Luca M, Cocco Lucio, Ratti Stefano, Martelli Alberto M, Laidler Piotr, Dulińska-Litewka Joanna, Rakus Dariusz, Gizak Agnieszka, Lombardi Paolo, Nicoletti Ferdinando, Candido Saverio, Libra Massimo, Montalto Giuseppe, Cervello Melchiorre
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
Department of Comparative Medicine, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
Aging (Albany NY). 2017 Jun 12;9(6):1477-1536. doi: 10.18632/aging.101250.
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (). CUR is currently used in the treatment of many disorders, especially in those involving an inflammatory process. CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants () and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. Understanding the benefits of these and other nutraceuticals may result in approaches to improve human health.
天然产物或营养保健品已被证明具有抗衰老、抗癌和其他增进健康的功效。天然产物作用的一个关键靶点可能是对微小RNA（miR）表达的调控，这会导致细胞死亡或预防衰老、糖尿病、心血管疾病及其他疾病。本综述将聚焦于几种天然产物，尤其是白藜芦醇（RES）、姜黄素（CUR）和黄连素（BBR）。RES来源于葡萄皮以及其他水果和浆果。RES可能通过激活去乙酰化酶和SIRT1分子来延长人类寿命。CUR是从姜黄根中分离出来的。CUR目前用于治疗多种病症，尤其是那些涉及炎症过程的病症。CUR及其修饰衍生物已被证明具有强大的抗癌作用，特别是对癌症干细胞（CSC）。BBR同样从多种植物中分离得到，并且在传统医学中已被使用了数百年，用于治疗诸如成年型糖尿病等疾病。了解这些及其他营养保健品的益处可能会带来改善人类健康的方法。
