Wu Xue, Yan Yaping, Zhang Qian
National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, The People's Republic of China.
J Inflamm Res. 2021 Nov 2;14:5713-5737. doi: 10.2147/JIR.S329864. eCollection 2021.
Spinal cord injury (SCI) is a severe traumatic injury of the central nervous system, characterized by neurological dysfunction and locomotor disability. Although the underlying pathological mechanism of SCI is complex and remains unclear, the important role of neuroinflammation has been gradually unveiled in recent years. The inflammation process after SCI involves disruption of the blood-spinal cord barrier (BSCB), activation of gliocytes, infiltration of peripheral macrophages, and feedback loops between different cells. Thus, our first aim is to illustrate pathogenesis, related cells and factors of neuroinflammation after SCI in this review. Due to the good bioactivity of natural products derived from plants and medicinal herbs, these widely exist as food, health-care products and drugs in our lives. In the inflammation after SCI, multiple natural products exert satisfactory effects. Therefore, the second aim of this review is to sum up the effects and mechanisms of 25 natural compounds and 7 extracts derived from plants or medicinal herbs on neuroinflammation after SCI. Clarification of the SCI inflammation mechanism and a summary of the related natural products is helpful for in-depth research and drug development.
脊髓损伤（SCI）是一种严重的中枢神经系统创伤性损伤，其特征为神经功能障碍和运动功能残疾。尽管SCI的潜在病理机制复杂且尚不清楚，但近年来神经炎症的重要作用已逐渐被揭示。SCI后的炎症过程涉及血脊髓屏障（BSCB）的破坏、神经胶质细胞的激活、外周巨噬细胞的浸润以及不同细胞之间的反馈回路。因此，我们在本综述中的首要目标是阐述SCI后神经炎症的发病机制、相关细胞和因素。由于源自植物和草药的天然产物具有良好的生物活性，它们在我们的生活中广泛作为食品、保健品和药物存在。在SCI后的炎症中，多种天然产物发挥了令人满意的作用。因此，本综述的第二个目标是总结25种天然化合物以及7种源自植物或草药的提取物对SCI后神经炎症的作用及机制。阐明SCI炎症机制并总结相关天然产物有助于深入研究和药物开发。
