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多酚类植物化学物质对甲状腺癌细胞系的抗增殖和再分化作用。

Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals.

机构信息

Department of Surgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

出版信息

J Korean Med Sci. 2011 Jul;26(7):893-9. doi: 10.3346/jkms.2011.26.7.893. Epub 2011 Jun 20.

DOI:10.3346/jkms.2011.26.7.893
PMID:21738342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3124719/
Abstract

Thyroid carcinogenesis is accompanied by loss of thyroid-specific functions and refractory to radioiodine and thyroid stimulating hormone (TSH) suppression therapy. Redifferentiating agents have been shown to inhibit tumor growth and improve the response to conventional therapy. Polyphenol phytochemicals (PPs) in fruits and vegetables have been reported to inhibit cancer initiation, promotion, progression and induce redifferentiation in selected types. In this study we examined PPs induce redifferentiation in thyroid cancer cell lines. We investigated the effects of genistein, resveratrol, quercetin, kaempferol, and resorcinol on the F9 embryonal carcinoma cell differentiation model. The thyroid cancer cell lines, TPC-1, FTC-133, NPA, FRO, and ARO, displayed growth inhibition in response to genistein, resveratrol, quercetin. We further demonstrated that genistein decreased the dedifferention marker CD97 in NPA cells and resveratrol decreased CD97 in FTC-133, NPA, FRO cells and quercetin decreased CD97 in all cell lines. We observed increased expression of differentiation marker NIS in FTC-133 cells in response to genistein, and resveratrol but no change in NPA, FRO, ARO cells. Quercetin increased or induced NIS in FTC-133, NPA, FRO cells. These findings suggest that PPs may provide a useful therapeutic intervention in thyroid cancer redifferentiation therapy.

摘要

甲状腺癌的发生伴随着甲状腺特异性功能的丧失，并且对放射性碘和甲状腺刺激激素（TSH）抑制治疗具有抗性。已经证明再分化剂能够抑制肿瘤生长并改善对常规治疗的反应。水果和蔬菜中的多酚类植物化学物质（PPs）已被报道能够抑制癌症的起始、促进、进展，并在某些类型中诱导再分化。在这项研究中，我们研究了 PPs 在甲状腺癌细胞系中的诱导再分化作用。我们研究了染料木黄酮、白藜芦醇、槲皮素、山奈酚和间苯二酚对 F9 胚胎癌细胞分化模型的影响。甲状腺癌细胞系 TPC-1、FTC-133、NPA、FRO 和 ARO 的生长均受到染料木黄酮、白藜芦醇、槲皮素的抑制。我们进一步证明，染料木黄酮降低了 NPA 细胞中的去分化标志物 CD97，白藜芦醇降低了 FTC-133、NPA、FRO 细胞中的 CD97，槲皮素降低了所有细胞系中的 CD97。我们观察到 FTC-133 细胞中 NIS 分化标志物的表达增加，对染料木黄酮和白藜芦醇有反应，但 NPA、FRO、ARO 细胞没有变化。槲皮素增加或诱导了 FTC-133、NPA、FRO 细胞中的 NIS。这些发现表明 PPs 可能为甲状腺癌再分化治疗提供有用的治疗干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/66301037da1c/jkms-26-893-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/40b1ec128748/jkms-26-893-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/a6bf39ab03db/jkms-26-893-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/c8acf976ff37/jkms-26-893-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/9cfdef252588/jkms-26-893-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/97495d3fcfd1/jkms-26-893-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/f876fd7fa9d9/jkms-26-893-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/66301037da1c/jkms-26-893-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/40b1ec128748/jkms-26-893-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/a6bf39ab03db/jkms-26-893-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/c8acf976ff37/jkms-26-893-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/9cfdef252588/jkms-26-893-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b7/3124719/f876fd7fa9d9/jkms-26-893-g006.jpg
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