The Y Chromosome Plays a Protective Role in Experimental Hypoxic Pulmonary Hypertension.
作者信息
Umar Soban, Cunningham Christine M, Itoh Yuichiro, Moazeni Shayan, Vaillancourt Mylene, Sarji Shervin, Centala Alex, Arnold Arthur P, Eghbali Mansoureh
机构信息
1 University of California, Los Angeles Los Angeles, California.
出版信息
Am J Respir Crit Care Med. 2018 Apr 1;197(7):952-955. doi: 10.1164/rccm.201707-1345LE.
Abstract
摘要
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本文引用的文献
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A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues.关于使用小鼠模型识别导致非性腺组织性别差异的直接性染色体效应的入门知识。
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Estrogen: Friend or Foe in Pulmonary Hypertension?雌激素：肺动脉高压中的朋友还是敌人？
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The importance of having two X chromosomes.拥有两条X染色体的重要性。
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Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.哺乳动物的 Y 染色体保留了广泛表达的剂量敏感调控因子。
Nature. 2014 Apr 24;508(7497):494-9. doi: 10.1038/nature13206.
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XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis.性染色体 XY 复合物与 XX 相比，在中枢神经系统中会导致实验性自身免疫性脑脊髓炎期间更大程度的神经退行性变。
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Genetics and genomics of pulmonary arterial hypertension.肺动脉高压的遗传学和基因组学。
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Molecular pathogenesis of pulmonary arterial hypertension.肺动脉高压的分子发病机制。
J Clin Invest. 2012 Dec;122(12):4306-13. doi: 10.1172/JCI60658. Epub 2012 Dec 3.
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Estrogen paradox in pulmonary hypertension: current controversies and future perspectives.肺动脉高压中的雌激素悖论：当前的争议和未来的展望。
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Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery.年龄和性别对慢性缺氧性肺动脉高压及恢复的影响。
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