Department of Sports Science and Clinical Biomechanics, Division of Exercise Epidemiology, Centre of Research in Childhood Health, University of Southern Denmark, Odense, Denmark
Department of Sports Science and Clinical Biomechanics, Division of Exercise Epidemiology, Centre of Research in Childhood Health, University of Southern Denmark, Odense, Denmark.
Diabetes Care. 2016 Oct;39(10):1745-51. doi: 10.2337/dc16-0269. Epub 2016 Aug 3.
To investigate the long-term association of exposure to perfluoroalkylated substances, including perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), during childhood (9 years) and adolescence (15 years) on indicators of adiposity and glucose metabolism in adolescence (15 years) and young adulthood (21 years). Secondarily, we aim to clarify the degree of tracking of exposure from childhood into young adulthood.
Data derived from a large multicenter prospective cohort study, in which the same participants have been observed from childhood (N = 590), during adolescence (N = 444), and into young adulthood (N = 369). Stored plasma samples were analyzed for PFOS and PFOA. Indicators of adiposity comprising body height, body weight, sum of four skinfolds, and waist circumference, as well as indicators of glucose metabolism, comprising fasting blood glucose, triglyceride, and insulin levels, β-cell function, and insulin resistance, have been collected at all study waves. Multiple linear regression was applied in order to model earlier exposure on later outcome while controlling for baseline outcome levels, sex, age, and socioeconomic factors.
Childhood exposure to PFOS was associated with indicators of adiposity at 15 years of age that are displayed in elevated BMI, skinfold thickness, and waist circumference, as well as increased skinfold thickness and waist circumference at 21 years of age. PFOA exposure in childhood was associated with decreased β-cell function at 15 years of age. We did not observe associations between exposure during adolescence and indicators of adiposity and glucose metabolism in young adulthood.
This study found evidence for childhood exposure to PFOS and PFOA predicting adiposity at 15 and 21 years of age and impaired β-cell function at 15 years of age, respectively.
研究儿童期（9 岁）和青春期（15 岁）暴露于全氟烷基物质（包括全氟辛烷磺酸[PFOS]和全氟辛酸[PFOA]）与青春期（15 岁）和青年期（21 岁）时肥胖和葡萄糖代谢指标的长期关联。其次，我们旨在阐明从儿童期到青年期暴露的跟踪程度。
本研究数据来源于一项大型多中心前瞻性队列研究，其中相同的参与者从儿童期（N=590）、青春期（N=444）到青年期（N=369）一直被观察。对储存的血浆样本进行 PFOS 和 PFOA 分析。肥胖指标包括身高、体重、四个皮褶厚度之和以及腰围，葡萄糖代谢指标包括空腹血糖、甘油三酯和胰岛素水平、β细胞功能和胰岛素抵抗，在所有研究阶段均有采集。应用多元线性回归来模拟早期暴露对晚期结果的影响，同时控制基线结果水平、性别、年龄和社会经济因素。
儿童期暴露于 PFOS 与 15 岁时的肥胖指标相关，表现为 BMI、皮褶厚度和腰围增加，以及 21 岁时皮褶厚度和腰围增加。儿童期暴露于 PFOA 与 15 岁时的β细胞功能下降有关。我们没有观察到青春期暴露与青年期肥胖和葡萄糖代谢指标之间的关联。
本研究发现，PFOS 和 PFOA 暴露于儿童期分别预测了 15 岁和 21 岁时的肥胖和 15 岁时的β细胞功能受损。
