Université de Lorraine, Neurotoxicologie Alimentaire et Bioactivité, Rue du Général Delestraint, Campus Bridoux, 57070 Metz, France.
Université de Lorraine, Neurotoxicologie Alimentaire et Bioactivité, Rue du Général Delestraint, Campus Bridoux, 57070 Metz, France.
Horm Behav. 2017 Nov;96:137-146. doi: 10.1016/j.yhbeh.2017.09.002. Epub 2017 Sep 29.
In social species, social interactions between conspecifics constitute a fundamental component to establish relations, provide best chances to reproduce, and even improve survival rates. In this study, a three-chambered social approach test was used to estimate the level of sociability and level of preference for social novelty in both male and female young adult (postnatal day (PND) 50) and middle-aged (PND 330) offspring mice (n=10 per group) that were perinatally exposed to a mixture of six polychlorinated biphenyls (PCBs), 28, 52, 101, 138, 153, and 180, at environmentally low doses (10 and 1000ng/kg b.w. for dams during gestation and lactation), a profile that closely mimics human exposure to contaminated fish. Our results showed that PCBs bidirectionally modulated social preferences in offspring mice, and the effects were sex and age dependent. However, increased levels of social interactions were rather frequently detected in both assays of the three-chambered test. Reduced social interaction was only induced in 1000ng/kg PCB-exposed middle-aged males, which exhibited similar preferences to social and non-social stimuli when compared to middle-aged controls. Furthermore, results showed that plasma levels of both corticosterone and acetylcholinesterase activity were higher in all PCB-exposed middle-aged males and females than in their control counterparts. In summary, although the effects of PCBs were only of moderate magnitude, our results suggest that a PCB mixture can act as an endocrine disruptor in offspring mice, disturbing the formation of normal social habits.
在社会性物种中，同种个体之间的社会互动是建立关系、提供最佳繁殖机会甚至提高存活率的基本组成部分。在这项研究中，使用了三室社交方法测试来评估亲代围产期暴露于六氯联苯（PCB）混合物（10 和 1000ng/kg b.w. 母体在妊娠期和哺乳期）的雄性和雌性幼鼠（50 日龄和 330 日龄，每组 10 只）的社交性水平和对社会新颖性的偏好水平。这种模式非常类似于人类接触受污染鱼类的情况。我们的结果表明，PCB 双向调节了后代小鼠的社交偏好，并且这种影响具有性别和年龄依赖性。然而，在三室测试的两个测试中，经常检测到社交互动水平的增加。只有在 1000ng/kg PCB 暴露的中年雄性中才诱导出社交互动减少，与中年对照组相比，它们对社交和非社交刺激表现出相似的偏好。此外，结果表明，所有暴露于 PCB 的中年雄性和雌性的血浆皮质酮和乙酰胆碱酯酶活性水平均高于其对照组。总之，尽管 PCB 的影响仅具有中等程度，但我们的结果表明，PCB 混合物可以作为后代小鼠的内分泌干扰物，干扰正常社交习惯的形成。
