Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA.
Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA.
Horm Behav. 2019 May;111:7-22. doi: 10.1016/j.yhbeh.2018.11.006. Epub 2018 Dec 4.
A contribution to SBN/ICN special issue. Endocrine-disrupting chemicals (EDCs) are pervasive in the environment. They are found in plastics and plasticizers (bisphenol A (BPA) and phthalates), in industrial chemicals such as polychlorinated biphenyls (PCBs), and include some pesticides and fungicides such as vinclozolin. These chemicals act on hormone receptors and their downstream signaling pathways, and can interfere with hormone synthesis, metabolism, and actions. Because the developing brain is particularly sensitive to endogenous hormones, disruptions by EDCs can change neural circuits that form during periods of brain organization. Here, we review the evidence that EDCs affect developing hypothalamic neuroendocrine systems, and change behavioral outcomes in juvenile, adolescent, and adult life in exposed individuals, and even in their descendants. Our focus is on social, communicative and sociosexual behaviors, as how an individual behaves with a same- or opposite-sex conspecific determines that individual's ability to exist in a community, be selected as a mate, and reproduce successfully.
为 SBN/ICN 特刊撰稿。内分泌干扰物（EDCs）在环境中普遍存在。它们存在于塑料和增塑剂（双酚 A（BPA）和邻苯二甲酸盐）、工业化学品如多氯联苯（PCBs）中，还包括一些杀虫剂和杀菌剂，如萎锈灵。这些化学物质作用于激素受体及其下游信号通路，并可能干扰激素的合成、代谢和作用。由于发育中的大脑对内源性激素特别敏感，EDCs 的干扰会改变大脑组织期间形成的神经回路。在这里，我们回顾了 EDC 影响发育中的下丘脑神经内分泌系统的证据，并改变了暴露个体在青少年和成年生活中的行为结果，甚至在其后代中也是如此。我们的重点是社交、沟通和社会性行为，因为个体与同性或异性同种动物的行为方式决定了该个体在社区中生存、被选为配偶和成功繁殖的能力。
