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短脉冲铒:钇铝石榴石激光治疗沙特患者贝克痣的疗效与安全性:一项初步研究。

Efficacy and safety of short-pulse erbium: Yttrium aluminum garnet laser treatment of Becker's nevus in Saudi patients: A pilot study.

作者信息

Al-Saif Fahad, Al-Mekhadab E, Al-Saif H

机构信息

Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Int J Health Sci (Qassim). 2017 Jul-Sep;11(3):14-17.

Abstract

OBJECTIVE

Becker's nevus (BN) is a benign cutaneous hamartoma. Although different types of lasers have been used to treat the pigmentary part of BN, to date, no definite treatment modality has been determined. The objective of this study is to evaluate the efficacy and safety of erbium: yttrium aluminum garnet (Er: YAG) laser treatment among Saudi patients with BN.

PATIENTS AND METHODS

A series of 10 patients (skin phototypes III-V) with BN underwent treatment with an Er: YAG laser. Biopsies were taken from all patients to confirm the diagnosis. Treatment consisted of using a 2940 nm Er: YAG laser (fluence 700 mj/cm, short pulse, 3 mm spot size). Each patient underwent one session with three to five passes (the endpoint of passes was pinpoint bleeding). Clinical outcome was assessed using digital photographic method, before each treatment session and after the final visit. Clinical assessment scores were determined at each follow-up visit.

RESULTS

Seven patients completed the study. All patients noticed a significant reduction in pigmentation. Five of the patients had good improvement, and the remaining two had moderate improvement. The mean reepithelialization time was 7 days, and post-treatment erythema was seen in all patients (mean follow-up of 6 weeks). Post-inflammatory hypopigmentation was observed in all patients. No untoward sequelae were observed during the study or follow-up period.

CONCLUSION

Er: YAG laser therapy can be an efficient modality for reducing the pigmentary part of BN. No scar formation, significant dyspigmentation, or recurrences were observed after 1 year.

摘要

目的

贝克痣(BN)是一种良性皮肤错构瘤。尽管已使用不同类型的激光治疗BN的色素沉着部分,但迄今为止,尚未确定明确的治疗方式。本研究的目的是评估铒:钇铝石榴石(Er:YAG)激光治疗沙特BN患者的疗效和安全性。

患者与方法

10例(皮肤光型III - V)BN患者接受了Er:YAG激光治疗。对所有患者进行活检以确诊。治疗采用2940 nm Er:YAG激光(能量密度700 mj/cm,短脉冲,光斑大小3 mm)。每位患者接受一次治疗,进行三至五次照射(照射终点为点状出血)。在每次治疗前和最后一次随访后,使用数码摄影方法评估临床结果。每次随访时确定临床评估评分。

结果

7例患者完成研究。所有患者均注意到色素沉着明显减轻。其中5例患者改善良好,其余2例改善中等。平均上皮化时间为7天,所有患者均出现治疗后红斑(平均随访6周)。所有患者均观察到炎症后色素减退。在研究或随访期间未观察到不良后遗症。

结论

Er:YAG激光治疗可作为减少BN色素沉着部分的有效方式。1年后未观察到瘢痕形成、明显色素沉着异常或复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee4/5604269/ef500b0049db/IJHS-11-14-g001.jpg

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