Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention , Wuhan, Hubei 430079, China.
Department of Epidemiology, College of Public Health, University of Iowa , Iowa City, Iowa 52242, United States.
Environ Sci Technol. 2017 Nov 7;51(21):12806-12814. doi: 10.1021/acs.est.7b03289. Epub 2017 Oct 20.
Evidence concerning the association between ambient gaseous air pollutant exposures and semen quality is sparse, and findings in previous studies remain largely inconsistent. We enrolled 1759 men and performed 2184 semen examinations at a large reproductive medical center in Wuhan, China, between 2013 and 2015. Inverse distance weighting interpolation was performed to estimate individual exposures to SO, NO, CO, and O during the entire period (lag 0-90 days) and key periods (lag 0-9, 10-14, 70-90 days) of sperm development. Linear mixed models were used to analyze exposure-response relationships. SO exposure with 0-90 days lag was significantly associated with monotonically decreased sperm concentration (β for each interquartile range increase of exposure: -0.14; 95% CI: -0.23, -0.05), sperm count (-0.21; -0.30, -0.12) and total motile sperm count (-0.16; -0.25, -0.08). Significant associations were observed for total and progressive motility only when SO exposure was at the highest quintile (all P < 0.05). Similar trends were observed for SO exposure with 70-90 days lag. NO, CO, or O exposure was not significantly associated with semen quality. Our results suggest that ambient SO exposure adversely affects semen quality and highlight the potential to improve semen quality by reducing ambient SO exposure during early stages of sperm development.
有关环境气态空气污染物暴露与精液质量之间关联的证据稀缺，且先前研究的结果在很大程度上仍不一致。我们在中国武汉的一家大型生殖医学中心招募了 1759 名男性，并于 2013 年至 2015 年期间进行了 2184 次精液检查。采用逆距离权重插值法估计个体在整个时期（滞后 0-90 天）和精子发育的关键时期（滞后 0-9、10-14、70-90 天）内暴露于 SO、NO、CO 和 O 的情况。采用线性混合模型分析暴露-反应关系。具有 0-90 天滞后的 SO 暴露与精子浓度呈单调下降显著相关（暴露每增加一个四分位间距的 β 值：-0.14；95%CI：-0.23，-0.05）、精子计数（-0.21；-0.30，-0.12）和总活动精子计数（-0.16；-0.25，-0.08）。仅当 SO 暴露处于最高五分位时，总活力和前向运动活力才与 SO 暴露呈显著相关（均 P<0.05）。70-90 天滞后的 SO 暴露也存在类似的趋势。NO、CO 或 O 暴露与精液质量无显著相关性。我们的研究结果表明，环境 SO 暴露会对精液质量产生不利影响，并强调了通过减少精子发育早期的环境 SO 暴露来改善精液质量的潜力。
