Piegari Mariana, Soria Elio A, Eynard Aldo R, Valentich Mirta A
a Cátedra de Biología Celular, Histología y Embriología, Instituto de Biología Celular, Facultad de Ciencias Médicas , Universidad Nacional de Córdoba , Enrique Barros, Córdoba , Argentina.
b Instituto de Investigaciones en Ciencias de la Salud (INICSA) , Universidad Nacional de Córdoba , CONICET, Enrique Barros, Córdoba , Argentina.
Nutr Cancer. 2017 Oct;69(7):1069-1074. doi: 10.1080/01635581.2017.1359319. Epub 2017 Sep 22.
Lung cancer is the leading cause of death by cancer, and is a major sanitary concern worldwide. Some nutrients, such as ω-9 fatty acids, have been proposed as anticancer agents. Thus, an olein-enriched diet was assayed in a murine model of lung adenocarcinoma (LAC-1) to evaluate neoplastic and paraneoplastic evolution in BALB/c mice. The organic assimilation of dietary fatty acids was confirmed in liver by gas chromatography. This experimental oleic acid-containing diet increased animal survival and tumour latency (analysed by the Kaplan-Meier method), improving neoplastic evolution and general status, with weak effects on the paraneoplastic syndrome (thymus atrophy, splenomegaly, splenocyte response to mitogen, blood anaemia, and leucocytosis). Tumour lipid oxidation was not involved. Thus, diet enrichment with olein, a natural source of the ω-9 oleic acid, significantly delayed progression of LAC-1 and increased tumour latency and mice survival. These results support its use in nutritional management of cancer, with further studies being encouraged.
肺癌是癌症致死的主要原因，也是全球主要的卫生问题。一些营养物质，如ω-9脂肪酸，已被提议作为抗癌剂。因此，在肺腺癌小鼠模型（LAC-1）中检测了富含油精的饮食，以评估BALB/c小鼠的肿瘤及肿瘤旁演变情况。通过气相色谱法在肝脏中证实了膳食脂肪酸的有机同化作用。这种含实验性油酸的饮食提高了动物存活率和肿瘤潜伏期（通过Kaplan-Meier方法分析），改善了肿瘤演变和一般状况，对肿瘤旁综合征（胸腺萎缩、脾肿大、脾细胞对有丝分裂原的反应、贫血和白细胞增多）影响较弱。肿瘤脂质氧化未参与其中。因此，用ω-9油酸的天然来源油精丰富饮食，可显著延迟LAC-1的进展，增加肿瘤潜伏期和小鼠存活率。这些结果支持将其用于癌症的营养管理，鼓励进一步研究。
