高表达的COL4A1基因有助于浸润性导管癌的增殖和迁移。
The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas.
作者信息
Jin Rongzhong, Shen Jia, Zhang Tiancheng, Liu Qiliang, Liao Caihua, Ma Hailin, Li Sijing, Yu Zhaoxia
机构信息
College of Biotechnology, Guilin Medical University, Guilin, China.
Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
出版信息
Oncotarget. 2017 Apr 21;8(35):58172-58183. doi: 10.18632/oncotarget.17345. eCollection 2017 Aug 29.
BACKGROUND
Invasive ductal carcinoma is a kind of very typical breast cancer. The goal of our research was to figure out the molecular mechanism of Invasive ductal carcinoma and to find out its potential therapy targets.
RESULTS
The total amount of 478 differentially expressed genes in Invasive ductal carcinoma which compared with normal breast epithelial cells were recognized. Functional enrichment analysis proved the most part of differentially expressed genes had connection with ECM-receptor interaction. The two genes lists were contrasted in PPI network, and miRNA regulation networks, The most two crucial genes were identified in our study, which may be helpful to improve Invasive ductal carcinoma treatment. Additionally, experimental results shows that the COL4A1 gene, one of identified genes, played important roles in both of proliferation and colony formation in Invasive ductal carcinoma.
CONCLUSIONS
Invasive ductal carcinoma could have connection with ECM-receptor mutations. These 9 vital genes could be an important part in the progression of Invasive ductal carcinoma and be offered as therapy targets and prognosis indicator. and the experimental results showed that one of the most crucial genes, COL4A1, was the key gene that influence the proliferation and colony formation of the Invasive ductal carcinoma cell.
背景
浸润性导管癌是一种非常典型的乳腺癌。我们研究的目的是弄清楚浸润性导管癌的分子机制，并找出其潜在的治疗靶点。
结果
识别出了与正常乳腺上皮细胞相比，浸润性导管癌中478个差异表达基因的总量。功能富集分析证明大部分差异表达基因与细胞外基质-受体相互作用有关。在蛋白质-蛋白质相互作用（PPI）网络和微小RNA（miRNA）调控网络中对比了这两个基因列表，在我们的研究中确定了两个最关键的基因，这可能有助于改善浸润性导管癌的治疗。此外，实验结果表明，所确定的基因之一COL4A1基因在浸润性导管癌的增殖和集落形成中均发挥重要作用。
结论
浸润性导管癌可能与细胞外基质-受体突变有关。这9个关键基因可能是浸润性导管癌进展的重要组成部分，并可作为治疗靶点和预后指标。并且实验结果表明，最关键的基因之一COL4A1是影响浸润性导管癌细胞增殖和集落形成的关键基因。
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