Department of Food Science, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Cell Mol Life Sci. 2018 Mar;75(5):815-831. doi: 10.1007/s00018-017-2657-z. Epub 2017 Sep 22.
Autophagy is a highly regulated process in eukaryotes to maintain homeostasis and manage stress responses. Understanding the regulatory mechanisms and key players involved in autophagy will provide critical insights into disease-related pathogenesis and potential clinical treatments. In this review, we describe the hallmark events involved in autophagy, from its initiation, to the final destruction of engulfed targets. Furthermore, based on structural and biochemical data, we evaluate the roles of key players in these processes and provide rationale as to how they control autophagic events in a highly ordered manner.
自噬是真核生物中一种高度调控的过程，用于维持体内平衡和管理应激反应。了解自噬过程中的调节机制和关键参与者将为疾病相关发病机制和潜在的临床治疗提供重要的见解。在这篇综述中，我们描述了自噬涉及的标志性事件，从其起始到被吞噬目标的最终破坏。此外，根据结构和生化数据，我们评估了这些过程中关键参与者的作用，并提供了它们如何以高度有序的方式控制自噬事件的基本原理。
