Hui Alex
School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia.
Clin Exp Optom. 2017 Sep;100(5):494-512. doi: 10.1111/cxo.12592.
Contact lenses as a means to deliver pharmaceuticals to the eye have seen a significant increase in research interest in the past few years. This review will detail the in vitro experiments which have investigated use of these contact lenses in the context of the desired pharmacological treatment goals in the management of infectious, inflammatory, allergic and glaucomatous diseases of the eye. The techniques researchers have employed to modify and tailor drug release rates from these materials, including the use of vitamin E diffusion barriers, modified ionicity, molecular imprinting and incorporation of drug reservoirs, will be discussed, as well as their impact on drug release kinetics. Finally, the demonstration of the feasibility of these materials when applied in vivo in animal models as well as in humans with and without disease will be presented and their results discussed relating to their implications for the future of the field.
在过去几年中，作为将药物递送至眼部的一种手段，隐形眼镜已引发了研究兴趣的显著增长。本综述将详细介绍体外实验，这些实验在眼部感染性、炎症性、过敏性和青光眼性疾病管理中，针对所需的药物治疗目标研究了这些隐形眼镜的用途。将讨论研究人员为改变和调整这些材料的药物释放速率所采用的技术，包括使用维生素E扩散屏障、改变离子性、分子印迹和引入药物储库，以及它们对药物释放动力学的影响。最后，将展示这些材料在动物模型以及患有和未患有疾病的人类体内应用时的可行性，并讨论其结果对该领域未来的意义。
