Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing, 100190, P. R. China.
Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Small. 2017 Nov;13(43). doi: 10.1002/smll.201701815. Epub 2017 Sep 20.
Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical issue for uncovering biomedical effects of NMs and facilitating their practical applications in the clinic. In this Review, by highlighting the differences of NMs cellular uptake between in vitro and in vivo, a focus on reviewing recent works about the effects of four physicochemical parameters of NMs (size, rigidity, shape, surface modification) on regulating NMs cellular uptake in vitro and in vivo is undertaken. This review can provide readers some useful clues and new thinking for understanding NMs cellular uptake in depth.
了解纳米材料（NMs）的细胞摄取对于揭示 NMs 的生物医学效应以及促进其在临床上的实际应用是一个基本而关键的问题。在这篇综述中，通过突出 NMs 细胞摄取在体外和体内的差异，重点回顾了关于 NMs 的四个物理化学参数（尺寸、刚性、形状、表面修饰）对调节 NMs 体外和体内细胞摄取的影响的最新研究工作。这篇综述可以为读者深入了解 NMs 的细胞摄取提供一些有用的线索和新的思路。
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