CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
Appl Biochem Biotechnol. 2012 Mar;166(6):1533-51. doi: 10.1007/s12010-012-9548-4. Epub 2012 Jan 26.
Gold nanomaterials (Au NMs) have attracted increasing attention in biomedicine due to their facile preparation, multifunctional modifications, unique optical and electrical properties, and good biocompatibility. The physicochemical properties of Au NMs at nanoscale, like size, shape, surface chemistry, and near field effects, are rendering Au NMs potent candidates in biomedicine. Thus, risk assessment of negative effects of Au NMs on biological systems is becoming urgent and necessary for future applications. In this review, we summarize up-to-date progresses on the preparation and modification of Au NMs and their biomedical applications, including biosensor, bioimaging and phototherapy, gene/drug delivery. Finally, we discuss the potential risk of Au NMs to biological systems, which is instructive for rationally designing and preparing nanomaterials for safe applications in nanomedicine.
金纳米材料（AuNMs）由于其易于制备、多功能修饰、独特的光学和电学性质以及良好的生物相容性，在生物医学领域引起了越来越多的关注。AuNMs 的纳米级物理化学性质，如尺寸、形状、表面化学和近场效应，使 AuNMs 成为生物医学领域的有力候选者。因此，评估 AuNMs 对生物系统的负面影响的风险对于未来的应用变得紧迫和必要。在这篇综述中，我们总结了 AuNMs 的制备和修饰及其在生物医学中的应用的最新进展，包括生物传感器、生物成像和光疗、基因/药物传递。最后，我们讨论了 AuNMs 对生物系统的潜在风险，这对于合理设计和制备纳米材料以安全应用于纳米医学具有指导意义。
