GSK-3 介导一氧化氮-cGMP 诱导的豆芽异黄酮的产生。
GSK-3 mediates NO-cGMP-induced isoflavone production in soybean sprouts.
机构信息
College of Life Science, Anqing Normal University, Anqing, Anhui 246133, People's Republic of China.
College of Life Science, Anqing Normal University, Anqing, Anhui 246133, People's Republic of China.
出版信息
Food Res Int. 2017 Nov;101:203-208. doi: 10.1016/j.foodres.2017.09.002. Epub 2017 Sep 7.
The role of glycogen synthase kinase-3 (GSK-3) in the nitric oxide-guanosine 3',5'-cyclic monophosphate (NO-cGMP)-induced isoflavone production in soybean sprouts was examined. Inhibitors and donors of NO, cGMP, and GSK-3 inhibitor were added to UV-B irradiated sprouts. Results showed that NO, with cGMP, induced the expression of GSK-3 under UV-B radiation. Protein kinase G (PKG) was shown to be involved in NO-cGMP-induced GSK-3 activation. GSK-3 elevated activity and expression levels of chalcone synthase (CHS) and isoflavone synthase (IFS), and increased isoflavone accumulation.
研究了一氧化氮-鸟苷 3',5'-环单磷酸（NO-cGMP）诱导大豆芽中异黄酮产生过程中糖原合成酶激酶-3（GSK-3）的作用。向 UV-B 辐射的豆芽中添加了 NO、cGMP 和 GSK-3 抑制剂的抑制剂和供体。结果表明，NO 与 cGMP 在 UV-B 辐射下诱导 GSK-3 的表达。显示蛋白激酶 G（PKG）参与 NO-cGMP 诱导的 GSK-3 激活。GSK-3 提高了查尔酮合酶（CHS）和异黄酮合酶（IFS）的活性和表达水平，并增加了异黄酮的积累。
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