多穗醉鱼草地上部分的化学成分及其对埃及伊蚊的生物活性
Chemical Composition of Buddleja polystachya Aerial Parts and its Bioactivity against Aedes aegypti.
作者信息
El-Gamal Ali, Al-Massarani Shaza, Fawzy Ghada, Ati Hanan, Al-Rehaily Adnan, Basudan Omer, Abdel-Kader Maged, Tabanca Nurhayat, Becnel James
机构信息
a Department of Pharmacognosy, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.
b Faculty of Pharmacy, Department of Pharmacognosy , Mansoura University , Mansoura , Egypt.
出版信息
Nat Prod Res. 2018 Dec;32(23):2775-2782. doi: 10.1080/14786419.2017.1378213. Epub 2017 Sep 25.
A new acylatediridoid glycoside, 6-O-α-L-(2″-acetyl-4″-O-trans-isoferuloyl) rhamnopyranosyl catalpol (9) together with 18 known compounds belonging to the iridoids, flavonoids, triterpene saponin glycosides and phenylethanoids (1-8, 10-18) were isolated from the aerial parts and the flowers of Buddleja polystachya. Their structures were elucidated on the basis of spectroscopic evidence and comparison with that reported in the literature. Promising adulticidal activity was shown for all extracts when tested for adulticidal and larvicidal activities against Ae. aegypti mosquitoes. Therefore, isolated compounds (1-10, 12-14 and 19) were bioassayed for their adulticidal activity. Compound 1 (phytol) was highly active with an LD value of 1.27 ± 0.08 μg/mosquito against adult female Ae. aegypti.
从多穗醉鱼草的地上部分和花中分离出一种新的酰化环烯醚萜苷，6-O-α-L-(2″-乙酰基-4″-O-反式异阿魏酰基)鼠李吡喃糖基梓醇(9)以及18种已知化合物，这些化合物属于环烯醚萜类、黄酮类、三萜皂苷糖苷和苯乙醇类(1 - 8,10 - 18)。它们的结构是根据光谱证据并与文献报道的结构进行比较而阐明的。当对所有提取物进行针对埃及伊蚊的成虫杀灭和幼虫杀灭活性测试时，均显示出有前景的成虫杀灭活性。因此，对分离出的化合物(1 - 10、12 - 14和19)进行了成虫杀灭活性生物测定。化合物1(叶绿醇)具有高活性，对成年雌性埃及伊蚊的半数致死剂量值为1.27±0.08μg/蚊子。
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