Owada Kei, Nielsen Mark, Lau Colleen L, Clements Archie C A, Yakob Laith, Soares Magalhães Ricardo J
School of Medicine, The University of Queensland, South Brisbane, QLD, Australia; Children's Health and Environment Program, Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia.
School of Psychology, The University of Queensland, St Lucia, QLD, Australia; Faculty of Humanities, University of Johannesburg, Auckland Park, South Africa.
Adv Parasitol. 2017;98:1-37. doi: 10.1016/bs.apar.2017.05.002. Epub 2017 Jun 2.
Recently the role of soil-transmitted helminth (STH) infections in children's cognitive developmental impairment has been under scrutiny. We conducted a systematic review of the evidence for associations between STH infections and cognitive function of children using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. We aimed to identify the domains of cognitive function in three age strata (<24months, 24-59months and ≥60months) and critically appraise the general design protocol of the studies, with a focus on the cognitive function measurement tools used. A total of 42 papers fulfilled the inclusion criteria, including 10 studies from a recent Cochrane review. Our findings demonstrate variation in tested domains, lack of consistency in the use of measurement tools and analysis of results. Cognitive function measures in children aged under 59months have been mainly limited to domains of gross motor, fine motor and language skills, whereas in children aged 60months and above most studies tested domains such as memory and processing speed. Even within the same age group the results on the association between STH infections and measures of cognitive development were often conflicting. The current study highlights the need for methodological consensus in the use of measurement tools and data analysis protocols if the effect of STH infections on cognitive function domains in children is to be correctly established. This will be an imperative next step to generate conclusive evidence of the role of STH infections in cognitive development in children.
最近，土壤传播的蠕虫（STH）感染在儿童认知发育障碍中的作用一直受到密切关注。我们使用系统评价和荟萃分析的首选报告项目协议，对STH感染与儿童认知功能之间关联的证据进行了系统评价。我们旨在确定三个年龄层（<24个月、24 - 59个月和≥60个月）的认知功能领域，并严格评估研究的总体设计方案，重点关注所使用的认知功能测量工具。共有42篇论文符合纳入标准，其中包括最近Cochrane综述中的10项研究。我们的研究结果表明，测试领域存在差异，测量工具的使用以及结果分析缺乏一致性。59个月以下儿童的认知功能测量主要限于大运动、精细运动和语言技能领域，而在60个月及以上的儿童中，大多数研究测试的领域如记忆和处理速度。即使在同一年龄组中，STH感染与认知发展测量之间关联的结果也常常相互矛盾。当前的研究强调，如果要正确确定STH感染对儿童认知功能领域的影响，在测量工具的使用和数据分析方案方面需要达成方法学上的共识。这将是下一步生成关于STH感染在儿童认知发展中作用的确凿证据的当务之急。
Zotero 插件