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鼠李糖乳杆菌 HN001 对妊娠产后抑郁和焦虑症状的影响：一项随机双盲安慰剂对照试验。

Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial.

机构信息

Department of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Department of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand.

出版信息

EBioMedicine. 2017 Oct;24:159-165. doi: 10.1016/j.ebiom.2017.09.013. Epub 2017 Sep 14.

DOI:10.1016/j.ebiom.2017.09.013
PMID:28943228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5652021/
Abstract

BACKGROUND: Probiotics may help to prevent symptoms of anxiety and depression through several putative mechanisms. OBJECTIVE: The aim of this study was to evaluate the effect of Lactobacillus rhamnosus HN001 (HN001) given in pregnancy and postpartum on symptoms of maternal depression and anxiety in the postpartum period. This was a secondary outcome, the primary outcome being eczema in the offspring at 12months of age. DESIGN, SETTING, PARTICIPANTS: A randomised, double-blind, placebo-controlled trial of the effect of HN001 on postnatal mood was conducted in 423 women in Auckland and Wellington, New Zealand. Women were recruited at 14-16weeks gestation. INTERVENTION: Women were randomised to receive either placebo or HN001 daily from enrolment until 6months postpartum if breastfeeding. OUTCOME MEASURES: Modified versions of the Edinburgh Postnatal Depression Scale and State Trait Anxiety Inventory were used to assess symptoms of depression and anxiety postpartum. TRIAL REGISTRATION: Australia NZ Clinical Trials Registry: ACTRN12612000196842. FINDINGS: 423 women were recruited between December 2012 and November 2014. 212 women were randomised to HN001 and 211 to placebo. 380 women (89.8%) completed the questionnaire on psychological outcomes, 193 (91.0%) in the treatment group and 187 (88.6%) in the placebo group. Mothers in the probiotic treatment group reported significantly lower depression scores (HN001 mean=7·7 (SD=5·4), placebo 9·0 (6·0); effect size -1·2, (95% CI -2·3, -0·1), p=0·037) and anxiety scores (HN001 12·0 (4·0), placebo 13·0 (4·0); effect size -1·0 (-1·9, -0·2), p=0·014) than those in the placebo group. Rates of clinically relevant anxiety on screening (score>15) were significantly lower in the HN001 treated mothers (OR=0·44 (0·26, 0·73), p=0·002). INTERPRETATION: Women who received HN001 had significantly lower depression and anxiety scores in the postpartum period. This probiotic may be useful for the prevention or treatment of symptoms of depression and anxiety postpartum. FUNDING SOURCE: Health Research Council of New Zealand (11/318) and Fonterra Co-operative Group Ltd.

摘要

背景：益生菌可能通过多种推测机制帮助预防焦虑和抑郁症状。

目的：本研究旨在评估鼠李糖乳杆菌 HN001（HN001）在妊娠和产后给予时对产后产妇抑郁和焦虑症状的影响。这是次要结局，主要结局是 12 个月龄时婴儿出现湿疹。

设计、地点、参与者：在新西兰奥克兰和惠灵顿的 423 名妇女中进行了一项随机、双盲、安慰剂对照试验，以评估 HN001 对产后情绪的影响。妇女在 14-16 周妊娠时招募。

干预措施：如果母乳喂养，妇女从入组开始至产后 6 个月每天随机分配接受安慰剂或 HN001。

结果：2012 年 12 月至 2014 年 11 月期间，423 名妇女入组。212 名妇女被随机分配到 HN001 组，211 名妇女分到安慰剂组。380 名妇女（89.8%）完成了心理结局问卷，治疗组 193 名（91.0%），安慰剂组 187 名（88.6%）。益生菌治疗组的母亲报告的抑郁评分明显较低（HN001 平均值=7.7（SD=5.4），安慰剂 9.0（6.0）；效应量-1.2，（95%CI-2.3，-0.1），p=0.037）和焦虑评分（HN001 12.0（4.0），安慰剂 13.0（4.0）；效应量-1.0（-1.9，-0.2），p=0.014），而安慰剂组的母亲则明显较低。HN001 治疗母亲的焦虑筛查（评分>15）的临床相关率明显较低（OR=0.44（0.26，0.73），p=0.002）。

解释：接受 HN001 的妇女在产后期间抑郁和焦虑评分明显较低。这种益生菌可能对预防或治疗产后抑郁和焦虑症状有用。

资金来源：新西兰健康研究委员会（11/318）和恒天然合作集团有限公司。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81dd/5652021/6d4d5c732ef0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81dd/5652021/6d4d5c732ef0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81dd/5652021/6d4d5c732ef0/gr1.jpg

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[1]
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[2]
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[7]
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[10]
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[10]
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本文引用的文献

[1]
Anxiogenic effects of a Lactobacillus, inulin and the synbiotic on healthy juvenile rats.

Neuroscience. 2017-9-17

[2]
Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals.

Nutrients. 2017-3-15

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Ann Gen Psychiatry. 2017-2-20

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A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression.

Aust N Z J Psychiatry. 2017-8

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Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects.

Brain Behav Immun. 2016-11-16

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Int Rev Neurobiol. 2016

[8]
Microbiome-Gut-Brain Axis: Probiotics and Their Association With Depression.

J Neuropsychiatry Clin Neurosci. 2017

[9]
The Probiotics in Pregnancy Study (PiP Study): rationale and design of a double-blind randomised controlled trial to improve maternal health during pregnancy and prevent infant eczema and allergy.

BMC Pregnancy Childbirth. 2016-6-3

[10]
Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials.

Genome Med. 2016-5-10

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