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Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children.

作者信息

Lai Peggy S, Massoud Amir H, Xia Mingcan, Petty Carter R, Cunningham Amparito, Chatila Talal A, Phipatanakul Wanda

机构信息

Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, Mass; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass; Harvard Medical School, Boston, Mass.

Harvard Medical School, Boston, Mass; Allergy and Immunology, Boston Children's Hospital, Boston, Mass.

出版信息

J Allergy Clin Immunol. 2018 Feb;141(2):794-796.e3. doi: 10.1016/j.jaci.2017.08.023. Epub 2017 Sep 21.

Abstract
摘要

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Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade.
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Early exposure to bio-contaminants and asthma up to 10 years of age: results of the HITEA study.
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