Tanaka Yuichiro, Sakata Yasuhisa, Hara Megumi, Kawakubo Hiroharu, Tsuruoka Nanae, Yamamoto Koji, Itoh Yoichiro, Hidaka Hidenori, Shimoda Ryo, Iwakiri Ryuichi, Fujimoto Kazuma
Departments of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, Japan.
Preventive Medicine, Saga Medical School, Japan.
Intern Med. 2017 Nov 15;56(22):2979-2983. doi: 10.2169/internalmedicine.8669-16. Epub 2017 Sep 25.
Objective The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. Methods Between 2010 and 2016, 550 fifth-year medical students at Saga Medical School, aged 22 to 30 years, underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease). H. pylori infection was determined by detecting urinary immunoglobulin G antibodies. Results H. pylori antibodies were detected in 45 of the 550 subjects (8.2%). Endoscopic reflux esophagitis was detected in 38 out of 550 (6.9%): grade A in 37 subjects (97.3%) and grade B in 1. Most subjects with reflux esophagitis were H. pylori-negative (35/37). Nodular gastritis was observed in 33.3% (15/45) of H. pylori-positive subjects. The risk factors for H. pylori infection were drinking well water in childhood, nodular gastritis, and duodenal ulcer scars. The risk factors for endoscopic reflux esophagitis were male gender and obesity (body mass index ≥25). Conclusion This study describes the risk factors for H. pylori infection and reflux esophagitis in healthy young Japanese subjects. The prevalence of reflux esophagitis was relatively high, and the infection rate of H. pylori was low compared with the aged Japanese population.
目的 本研究旨在确定健康日本年轻志愿者中反流性食管炎和幽门螺杆菌（H.pylori）感染的患病率、危险因素及其相互关系。方法 在2010年至2016年期间，对550名年龄在22至30岁之间的佐贺医科大学五年级医学生进行了上消化道内镜检查，并完成了一份问卷（胃食管反流病症状频率量表）。通过检测尿免疫球蛋白G抗体来确定H.pylori感染情况。结果 550名受试者中有45人（8.2%）检测到H.pylori抗体。550人中有38人（6.9%）经内镜检查发现反流性食管炎：37名受试者为A级（97.3%），1名受试者为B级。大多数反流性食管炎患者H.pylori呈阴性（35/37）。在H.pylori阳性受试者中，33.3%（15/45）观察到结节性胃炎。H.pylori感染的危险因素包括儿童时期饮用井水、结节性胃炎和十二指肠溃疡瘢痕。内镜下反流性食管炎 的危险因素为男性和肥胖（体重指数≥25）。结论 本研究描述了健康日本年轻受试者中H.pylori感染和反流性食管炎的危险因素。反流性食管炎的患病率相对较高，与老年日本人群相比，H.pylori感染率较低。
