Departments of Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
Departments of Preventive Medicine, Saga Medical School, Saga, Japan.
Esophagus. 2018 Apr;15(2):83-87. doi: 10.1007/s10388-017-0598-0. Epub 2017 Dec 19.
The aim of this study was to evaluate the differences in upper gastrointestinal symptoms between generations and genders in relatively healthy Japanese subjects.
Altogether, 4086 healthy Japanese male and female (M/F) adults (M/F: 2244/1842) were analyzed. Among them, 3505 subjects (M/F: 1922/1583) were underwent a routine medical checkup at one of five hospitals in Saga, Japan from January 2013 to December 2013. The others were 581 (M/F: 322/259) healthy young volunteers at the Saga Medical School from April 2007 to March 2013. The participants were asked to complete the frequency scale for the symptoms of gastroesophageal reflex disease (FSSG) questionnaire, undergo upper gastrointestinal endoscopy, and submit to a rapid urease test to diagnose Helicobacter pylori infection. Among the 4086 subjects, the 2414 who had no H. pylori infection and no positive endoscopic findings were enrolled in the study.
Subjects' average age was 46.9 ± 12.2 years, with males' and females' ages being almost equivalent. The total FSSG score were high in females compared to males (P < 0.01) and decreased significantly with aging (P < 0.05). Among the generations, FSSG scores were the highest for those 20-29 years old, and they were significantly decreased with ageing in both males and females (P < 0.05).
The FSSG score was significantly higher in healthy Japanese females than in males, and the scores decreased with aging.
本研究旨在评估日本相对健康的受试者中，代际和性别之间上消化道症状的差异。
共分析了 4086 名日本男性和女性（男/女：2244/1842）健康成年人。其中，3505 名受试者（男/女：1922/1583）于 2013 年 1 月至 12 月在日本佐贺的五家医院进行了常规体检。其余 581 名（男/女：322/259）为 2007 年 4 月至 2013 年 3 月在佐贺医科大学的健康年轻志愿者。要求参与者完成胃食管反流病症状频率量表（FSSG）问卷，接受上消化道内镜检查，并进行快速尿素酶试验以诊断幽门螺杆菌感染。在 4086 名受试者中，有 2414 名没有感染 H. pylori 和内镜阳性发现的人被纳入研究。
受试者的平均年龄为 46.9±12.2 岁，男性和女性的年龄几乎相等。女性的总 FSSG 评分高于男性（P<0.01），并随年龄增长而显著降低（P<0.05）。在各代中，20-29 岁的 FSSG 评分最高，男性和女性的评分均随年龄增长而显著降低（P<0.05）。
健康日本女性的 FSSG 评分明显高于男性，且评分随年龄增长而降低。
