Cui Li-Jun, Li Di-Chen, Liu Jian, Zhang Lei, Xing Yao
Department of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Institute of Advanced Manufacturing Technology, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Int J Ophthalmol. 2017 Sep 18;10(9):1354-1360. doi: 10.18240/ijo.2017.09.04. eCollection 2017.
To evaluate the intraocular pressure (IOP) control of an artificial trabeculum drainage system (ATDS), a newly designed glaucoma drainage device, and postoperative complications in normal rabbit eyes.
Pressure drops in air and fluid of 30 ATDS were measured after being connected to a closed manometric system. Twenty of them were then chosen and implanted randomly into the eyes of 20 rabbits. Postoperative slit-lamp, gonioscopic examination and IOP measurements were recorded periodically. Ultrasound biomicroscopy and B-scan ultrasonography were also used to observe the complications. Eyes were enucleated on day 60.
Pressure drops of 4.6-9.4 mm Hg were obtained at physiological aqueous flow rates in the tests The average postoperative IOP of the experimental eyes (11.6-12.8 mm Hg) was lower than the controls significantly (<0.05) at each time point. Complications of hemorrhage (=1), cellulosic exudation (two cases) and local iris congestion (two cases) were observed. The lumina of the devices were devoid of obstructions in all specimens examined and a thin fibrous capsule was found around the endplate.
ATDS reduce IOP effectively. However, further studies on the structure are needed to reduce complications.
评估一种新设计的青光眼引流装置——人工小梁引流系统（ATDS）对正常兔眼的眼压控制情况及术后并发症。
将30个ATDS连接到封闭测压系统后，测量其在空气和液体中的压力降。然后从中随机选取20个植入20只兔眼。定期记录术后裂隙灯、前房角镜检查及眼压测量结果。还采用超声生物显微镜和B超检查观察并发症情况。术后60天摘除眼球。
在生理房水流量测试中，压力降为4.6 - 9.4毫米汞柱。实验眼术后各时间点的平均眼压（11.6 - 12.8毫米汞柱）显著低于对照组（<0.05）。观察到的并发症有出血（1例）、纤维素渗出（2例）和局部虹膜充血（2例）。在所有检查标本中，装置管腔均无阻塞，终板周围发现一层薄纤维囊。
ATDS能有效降低眼压。然而，需要对其结构进行进一步研究以减少并发症。
