寻找一种使个体易患双相情感障碍（BPI）的基因。

Search for a gene that predisposes individuals to BPI disorder.

作者信息

Gerhard D S, Egeland J A, Pauls D L, Housman D E

机构信息

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.

出版信息

J Psychiatr Res. 1987;21(4):569-75. doi: 10.1016/0022-3956(87)90106-3.

DOI:10.1016/0022-3956(87)90106-3

PMID:2894460

Abstract

To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnoses and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.

摘要

为了确定遗传学在双相情感障碍中的作用，有必要进行正确的诊断并拥有大量同质人群。为了识别与该疾病相关的标记，另外两个因素很重要，即正确的遗传传递模型和高度多态性的DNA标记。确定了相关标记后，目标是识别易感基因。两种方法分别是预测候选基因和/或确定该区域的物理图谱。