狼毒大戟根中的二萜类化合物及其对α-葡萄糖苷酶的抑制作用。
Diterpenoids from the roots of Euphorbia fischeriana and their inhibitory effects on α-glucosidase.
作者信息
Wei Yun-Long, Yu Zhen-Long, Huo Xiao-Kui, Tian Xiang-Ge, Feng Lei, Huang Shan-Shan, Deng Sa, Ma Xiao-Chi, Jia Jing-Ming, Wang Chao
机构信息
a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
b College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology , Dalian Medical University , Dalian 116044 , China.
出版信息
J Asian Nat Prod Res. 2018 Oct;20(10):977-984. doi: 10.1080/10286020.2017.1367923. Epub 2017 Sep 25.
Chemical investigation has been performed on the roots of Euphorbia fischeriana, a traditional Chinese medicine. Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D NMR, 2D NMR, ECD, and calculated ECD, which gave two new diterpenoids, daphnane type (1) and ent-pimarene type (3). Additionally, the isolated compounds (1-3) displayed moderate inhibitory effects against α-glucosidase in an in vitro bioassay.
对传统中药狼毒大戟的根进行了化学研究。采用多种色谱技术得到了三种二萜类化合物，并通过高分辨电喷雾电离质谱（HRESIMS）、一维核磁共振（1D NMR）、二维核磁共振（2D NMR）、电子圆二色谱（ECD）和计算电子圆二色谱等光谱数据确定了它们的结构，从中得到了两种新的二萜类化合物，瑞香烷型（1）和对映-海松烷型（3）。此外，在体外生物测定中，分离得到的化合物（1-3）对α-葡萄糖苷酶显示出中等程度的抑制作用。
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