• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

植物化学分析、体外和体内抗氧化活性及不同提取物的理论计算

Phytochemical Analysis, Antioxidant Activities In Vitro and In Vivo, and Theoretical Calculation of Different Extracts of .

机构信息

College of Pharmacy, Yanbian University, Yanji 133000, China.

Green Medicinal Chemistry Laboratory, School of Pharmacy and Medicine, Tonghua Normal University, Tonghua 134002, China.

出版信息

Molecules. 2023 Jul 2;28(13):5172. doi: 10.3390/molecules28135172.

DOI:10.3390/molecules28135172
PMID:37446834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10343448/
Abstract

has a long-standing history of use in traditional medicine for the treatment of tuberculosis diseases. However, the plant's therapeutic potential extends beyond this specific ailment. The present study aimed to investigate the antioxidant properties of and lay the groundwork for further research on its potential therapeutic applications. Phytochemical tests were performed on the plant, and 11 types of phytochemicals were identified. Ultraviolet-visible spectrophotometry was used to evaluate the active components and antioxidant properties of eight different solvent extracts, ultimately selecting acetone extract for further research. UHPLC-ESI-Q-TOF-MS identified 43 compounds in the acetone extract, and chemical calculations were used to isolate those with high content and antioxidant activity. Three stability experiments confirmed the extract's stability, while cell viability and oral acute toxicity studies demonstrated its relatively low toxicity. In rats, the acetone extract showed significant protective effects against D-galactosamine-induced liver damage through histopathological examination and biochemical analysis. These results suggest that 's acetone extract has potential in treating diseases related to oxidative imbalances. Therefore, this study highlights the plant's potential therapeutic applications while providing insight into its antioxidant properties.

摘要

在传统医学中，被长期用于治疗结核病。然而，该植物的治疗潜力不仅限于此特定疾病。本研究旨在研究 的抗氧化特性，并为其潜在的治疗应用研究奠定基础。对该植物进行了植物化学测试，并鉴定出 11 种植物化学物质。利用紫外可见分光光度法评估了八种不同溶剂提取物的活性成分和抗氧化特性，最终选择丙酮提取物进行进一步研究。UHPLC-ESI-Q-TOF-MS 鉴定出丙酮提取物中的 43 种化合物，并通过化学计算分离出具有高含量和抗氧化活性的化合物。通过三项稳定性实验证实了提取物的稳定性，同时细胞活力和口服急性毒性研究表明其毒性相对较低。在大鼠中，丙酮提取物通过组织病理学检查和生化分析显示出对 D-半乳糖胺诱导的肝损伤有显著的保护作用。这些结果表明，的丙酮提取物在治疗与氧化失衡相关的疾病方面具有潜力。因此，本研究强调了该植物的潜在治疗应用，并提供了其抗氧化特性的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a4356e7de30c/molecules-28-05172-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/06f5a2a9466a/molecules-28-05172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/06f69f94ca3d/molecules-28-05172-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/9b32707b699d/molecules-28-05172-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/c172972c1183/molecules-28-05172-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/e50560925d9f/molecules-28-05172-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a1bd60cb3b82/molecules-28-05172-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a53c38b1f3e1/molecules-28-05172-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/5c6e5ccd0a66/molecules-28-05172-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/2f9f3e893473/molecules-28-05172-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a71fae412fd9/molecules-28-05172-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/f518a767ac44/molecules-28-05172-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/e44439848811/molecules-28-05172-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a2f0d852cdc1/molecules-28-05172-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/417e4e106ac0/molecules-28-05172-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/0d1195d8f973/molecules-28-05172-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a4356e7de30c/molecules-28-05172-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/06f5a2a9466a/molecules-28-05172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/06f69f94ca3d/molecules-28-05172-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/9b32707b699d/molecules-28-05172-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/c172972c1183/molecules-28-05172-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/e50560925d9f/molecules-28-05172-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a1bd60cb3b82/molecules-28-05172-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a53c38b1f3e1/molecules-28-05172-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/5c6e5ccd0a66/molecules-28-05172-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/2f9f3e893473/molecules-28-05172-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a71fae412fd9/molecules-28-05172-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/f518a767ac44/molecules-28-05172-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/e44439848811/molecules-28-05172-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a2f0d852cdc1/molecules-28-05172-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/417e4e106ac0/molecules-28-05172-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/0d1195d8f973/molecules-28-05172-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7d9/10343448/a4356e7de30c/molecules-28-05172-g016.jpg

相似文献

1
Phytochemical Analysis, Antioxidant Activities In Vitro and In Vivo, and Theoretical Calculation of Different Extracts of .植物化学分析、体外和体内抗氧化活性及不同提取物的理论计算
Molecules. 2023 Jul 2;28(13):5172. doi: 10.3390/molecules28135172.
2
Phytochemical Analysis and Antioxidant Activities of Various Extracts from the Aerial Part of Turcz.: In Vitro and In Vivo Studies.植物化学成分分析及不同提取方法对Turcz.地上部分的抗氧化活性研究：体内和体外研究。
Molecules. 2024 Sep 27;29(19):4602. doi: 10.3390/molecules29194602.
3
Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): Traditional uses, clinical applications, phytochemistry, pharmacology and toxicology.关于大飞扬草（大戟科）的现有知识：传统用途、临床应用、植物化学、药理学和毒理学。
J Ethnopharmacol. 2021 Jul 15;275:114095. doi: 10.1016/j.jep.2021.114095. Epub 2021 Apr 2.
4
Efficacy of Euphorbia helioscopia in context to a possible connection between antioxidant and antidiabetic activities: a comparative study of different extracts.泽漆在抗氧化与抗糖尿病活性可能联系方面的功效：不同提取物的比较研究
BMC Complement Med Ther. 2021 Feb 12;21(1):62. doi: 10.1186/s12906-021-03237-x.
5
Evaluating the Root Extract of (Nakai) Moldenke: An Analysis of Active Constituents, Antioxidant Potential, and Investigation of Hepatoprotective Effects in Rats.评价 （Nakai）Moldenke 根提取物：活性成分分析、抗氧化潜力及对大鼠肝保护作用的研究。
Molecules. 2024 Oct 4;29(19):4701. doi: 10.3390/molecules29194701.
6
Studies on phytochemical, antioxidant, anti-inflammatory and analgesic activities of Euphorbia dracunculoides.龙葵大戟的植物化学、抗氧化、抗炎和镇痛活性研究。
BMC Complement Altern Med. 2015 Oct 7;15:349. doi: 10.1186/s12906-015-0868-0.
7
Gold nanoparticles synthesized from Euphorbia fischeriana root by green route method alleviates the isoprenaline hydrochloride induced myocardial infarction in rats.采用绿色路线法从大戟根中合成的金纳米粒子可减轻盐酸异丙肾上腺素诱导的大鼠心肌梗死。
J Photochem Photobiol B. 2020 Jan;202:111705. doi: 10.1016/j.jphotobiol.2019.111705. Epub 2019 Nov 13.
8
Phytochemical composition analysis and evaluation of medicinal properties and cytotoxicity of five wild weeds: A comparative study.五种野生杂草的化学成分分析及药用特性和细胞毒性评价：比较研究。
F1000Res. 2020 Jun 2;9:493. doi: 10.12688/f1000research.22966.1. eCollection 2020.
9
Chemical profiling of Euphorbia fischeriana Steud. by UHPLC-Q/TOF-MS.利用 UHPLC-Q/TOF-MS 对大飞扬草进行化学特征分析。
J Pharm Biomed Anal. 2018 Mar 20;151:126-132. doi: 10.1016/j.jpba.2017.12.051. Epub 2017 Dec 26.
10
Phytochemical and cytotoxic studies on the roots of Euphorbia fischeriana.狼毒大戟根的植物化学与细胞毒性研究
Bioorg Med Chem Lett. 2017 Jan 15;27(2):266-270. doi: 10.1016/j.bmcl.2016.11.063. Epub 2016 Nov 23.

引用本文的文献

1
Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile.异叶大戟对链脲佐菌素诱导的糖尿病大鼠睾丸变性的保护作用及其植物化学特征
PLoS One. 2025 Jan 16;20(1):e0314781. doi: 10.1371/journal.pone.0314781. eCollection 2025.
2
Evaluating the Root Extract of (Nakai) Moldenke: An Analysis of Active Constituents, Antioxidant Potential, and Investigation of Hepatoprotective Effects in Rats.评价 （Nakai）Moldenke 根提取物：活性成分分析、抗氧化潜力及对大鼠肝保护作用的研究。
Molecules. 2024 Oct 4;29(19):4701. doi: 10.3390/molecules29194701.
3

本文引用的文献

1
Biological Function of Plant Tannin and Its Application in Animal Health.植物单宁的生物学功能及其在动物健康中的应用
Front Vet Sci. 2022 Jan 10;8:803657. doi: 10.3389/fvets.2021.803657. eCollection 2021.
2
Jolkinolide B attenuates laryngeal cancer cell growth and induces apoptosis via PTEN/PI3K/Akt signaling pathway.乔利罂粟碱 B 通过 PTEN/PI3K/Akt 信号通路抑制喉癌细胞生长并诱导细胞凋亡。
In Vitro Cell Dev Biol Anim. 2021 Sep;57(8):786-794. doi: 10.1007/s11626-021-00612-3. Epub 2021 Oct 25.
3
Anti-fatigue effects of fermented soybean protein peptides in mice.
Phytochemical Analysis and Antioxidant Activities of Various Extracts from the Aerial Part of Turcz.: In Vitro and In Vivo Studies.
植物化学成分分析及不同提取方法对Turcz.地上部分的抗氧化活性研究：体内和体外研究。
Molecules. 2024 Sep 27;29(19):4602. doi: 10.3390/molecules29194602.
4
Antioxidant and Anti-Inflammatory Activity of the Ethanolic Extract of Leaf Extract: An and Study.叶提取物乙醇提取物的抗氧化和抗炎活性：一项[未提及具体内容]研究 。 （原文中“An and Study”表述不完整，可能存在信息缺失）
J Pharm Bioallied Sci. 2024 Apr;16(Suppl 2):S1304-S1307. doi: 10.4103/jpbs.jpbs_591_23. Epub 2024 Apr 16.
5
(Sieb. et Zucc.) Planch. ex Miq.: A Review of Phytochemistry and Pharmacology.(Sieb.et Zucc.) Planch. ex Miq.: 植物化学与药理学综述。
Molecules. 2023 Nov 28;28(23):7820. doi: 10.3390/molecules28237820.
6
Boiss Derived Silver Nanoparticles and Their Applications as a Nanotherapeutic Agent to Control Microbial and Oxidative Stress-Originated Diseases.博伊斯衍生的银纳米颗粒及其作为纳米治疗剂用于控制微生物和氧化应激引发疾病的应用。
Pharmaceuticals (Basel). 2023 Oct 4;16(10):1413. doi: 10.3390/ph16101413.
发酵大豆蛋白肽对小鼠的抗疲劳作用。
J Sci Food Agric. 2022 May;102(7):2693-2703. doi: 10.1002/jsfa.11609. Epub 2021 Nov 10.
4
Bisfischoids A and B, dimeric ent-abietane-type diterpenoids with anti-inflammatory potential from Euphorbia fischeriana Steud.双贝壳杉烷 A 和 B，来自大戟属植物 Euphorbia fischeriana Steud 的具有潜在抗炎作用的二聚型贝壳杉烷型二萜。
Bioorg Chem. 2021 Nov;116:105356. doi: 10.1016/j.bioorg.2021.105356. Epub 2021 Sep 15.
5
Jolkinolide B inhibits proliferation or migration and promotes apoptosis of MCF-7 or BT-474 breast cancer cells by downregulating the PI3K-Akt pathway.杰枯枯灵 B 通过下调 PI3K-Akt 通路抑制 MCF-7 或 BT-474 乳腺癌细胞的增殖或迁移，促进其凋亡。
J Ethnopharmacol. 2022 Jan 10;282:114581. doi: 10.1016/j.jep.2021.114581. Epub 2021 Aug 28.
6
A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids.乌头生物碱的药理活性、毒理学机制及药代动力学研究的系统评价。
Chin J Nat Med. 2021 Jul;19(7):505-520. doi: 10.1016/S1875-5364(21)60050-X.
7
Application of carbohydrates in approved small molecule drugs: A review.碳水化合物在已批准的小分子药物中的应用：综述。
Eur J Med Chem. 2021 Nov 5;223:113633. doi: 10.1016/j.ejmech.2021.113633. Epub 2021 Jun 17.
8
Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): Traditional uses, clinical applications, phytochemistry, pharmacology and toxicology.关于大飞扬草（大戟科）的现有知识：传统用途、临床应用、植物化学、药理学和毒理学。
J Ethnopharmacol. 2021 Jul 15;275:114095. doi: 10.1016/j.jep.2021.114095. Epub 2021 Apr 2.
9
Analytical Methods Used in Determining Antioxidant Activity: A Review.分析方法在测定抗氧化活性中的应用：综述。
Int J Mol Sci. 2021 Mar 25;22(7):3380. doi: 10.3390/ijms22073380.
10
β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A Review.β-胡萝卜素：预防 2 型糖尿病和肥胖的作用：综述。
Molecules. 2020 Dec 9;25(24):5803. doi: 10.3390/molecules25245803.