Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, P. R. China.
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Chem Biodivers. 2021 Feb;18(2):e2000919. doi: 10.1002/cbdv.202000919. Epub 2021 Feb 2.
Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Their chemical structures and absolute configurations were determined by interpretation of NMR, HR-ESI-MS, ECD and X-ray diffraction data. Euphorfischerin A showed cytotoxicity against the human cancer cell lines HeLa, H460 and Namalwa with IC values of 4.6, 11.5 and 16.4 μM, respectively, while euphorfischerin B gave comparable IC values of 9.5, 17.4 and 13.3 μM against the three cancer cell lines, respectively.
从大飞扬Euphorbia fischeriana 的根部分离得到五个新的二萜，命名为 euphorfischerins A-E。通过 NMR、HR-ESI-MS、ECD 和 X 射线衍射数据分析确定了它们的化学结构和绝对构型。Euphorfischerin A 对人癌细胞系 HeLa、H460 和 Namalwa 的细胞毒性分别为 4.6、11.5 和 16.4 μM，而 euphorfischerin B 对这三种癌细胞系的 IC 值分别为 9.5、17.4 和 13.3 μM。
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